Low level light therapy for enhancement of neurologic function
First Claim
1. A method for enhancing neurologic function in a subject, said method comprising:
- providing a subject having a loss of neurologic function due to Parkinson'"'"'s disease or Alzheimer'"'"'s disease; and
noninvasively delivering a neurologic function enhancing effective amount of light energy having a wavelength in the visible to near-infrared wavelength range and a predetermined power density to the brain of the subject, wherein noninvasively delivering the neurologic function enhancing effective amount of light energy comprises transmitting light energy through the scalp and the skull to the brain, wherein the predetermined power density is at least about 0.01 mW/cm2 at a depth of approximately 2 centimeters below the dura.
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Abstract
Therapeutic methods for enhancing neurologic function such as may be desired in individuals having motor and/or cognitive impairment, including that resulting from Alzheimer'"'"'s disease, dementia, head trauma, mental disease such as depression, stroke and neurodegeneration, as well as in healthy individuals are described, the methods including delivering a cognitive enhancing effective amount of light energy having a wavelength in the visible to near-infrared wavelength range to a target area of the brain. The neurologic function enhancing effective amount of light energy, in accordance with a preferred embodiment, is a predetermined power density (mW/cm2) at the level of the brain tissue being treated, and is delivered by determining a surface power density of the light energy that is sufficient to deliver the predetermined power density of light energy to the target brain tissue. In one embodiment, progenitor cells are treated using light energy and implanted into the central nervous system of a patient.
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Citations
22 Claims
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1. A method for enhancing neurologic function in a subject, said method comprising:
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providing a subject having a loss of neurologic function due to Parkinson'"'"'s disease or Alzheimer'"'"'s disease; and noninvasively delivering a neurologic function enhancing effective amount of light energy having a wavelength in the visible to near-infrared wavelength range and a predetermined power density to the brain of the subject, wherein noninvasively delivering the neurologic function enhancing effective amount of light energy comprises transmitting light energy through the scalp and the skull to the brain, wherein the predetermined power density is at least about 0.01 mW/cm2 at a depth of approximately 2 centimeters below the dura. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of increasing neurologic function by increasing the production of ATP by neurons, comprising:
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noninvasively irradiating neurons of a subject having a loss of neurologic function due to Parkinson'"'"'s disease or Alzheimer'"'"'s disease with light energy with a predetermined power density and having a wavelength in the near infrared to visible portion of the electromagnetic spectrum for at least about 1 second; wherein the predetermined power density of said light energy at the neurons is at least about 0.01 mW/cm2 at a depth of approximately 2 centimeters below the dura, whereby the ATP production of neurons is increased. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A method for enhancing neurologic function in a subject, said method comprising:
noninvasively delivering a neurologic function enhancing effective amount of light energy through the scalp and the skull to the brain of a subject having a loss of neurologic function due to Parkinson'"'"'s disease or Alzheimer'"'"'s disease, the light energy having a wavelength in the visible to near-infrared wavelength range and a predetermined power density to the brain of at least about 0.01 mW/cm2 at a depth of approximately 2 centimeters below the dura. - View Dependent Claims (19, 20, 21, 22)
Specification