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Methods for producing ligand arrays

  • US 7,534,563 B2
  • Filed: 06/30/2003
  • Issued: 05/19/2009
  • Est. Priority Date: 06/30/2003
  • Status: Active Grant
First Claim
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1. A method of producing an array of at least two different ligands covalently bonded to a surface of a substrate, said method comprising:

  • (a) providing a substrate having a surface displaying photocleavable functional groups by contacting a surface of a substrate with a first silanizing reagent comprising a terminal photocleavable functional group to produce a surface displaying photocleavable functional groups;

    (b) cleaving said photocleavable functional groups on said surface to produce a patterned surface displaying feature regions of photocleavage produced functional groups; and

    (c) producing by in situ synthesis at least two different polymeric ligands in at least two different feature regions to produce said array;

    wherein said method includes a single photocleavage step that occurs prior to said producing step (c) and wherein said photocleavage produced functional groups are hydroxyl groups.

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