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Methods for enhancing antibody-induced cell lysis and treating cancer

  • US 7,534,772 B2
  • Filed: 06/22/2001
  • Issued: 05/19/2009
  • Est. Priority Date: 06/22/2000
  • Status: Expired due to Fees
First Claim
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1. A method for treating a subject having a B-cell malignancy resistant to therapy with an antibody specific for a surface antigen selected from CD19, CD20, and CD22, wherein cells of the malignancy have low or no baseline expression of the surface antigen, the method comprising:

  • administering to the subject the immunostimulatory CpG oligonucleotide ODN 2006 (SEQ ID NO;

    729) comprising a backbone modification and an unmethylated C, in an effective amount to upregulate expression of the surface antigen by the cells; and

    administering to the subject an antibody specific for the upregulated surface antigen, in an effective amount to treat the subject.

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