Modulation of exon recognition in pre-mRNA by interfering with the secondary RNA structure
First Claim
Patent Images
1. An isolated oligonucleotide of between 20 to 50 nucleotides comprising a sequence consisting of SEQ ID:
- 27.
1 Assignment
0 Petitions
Reexamination
Accused Products
Abstract
The invention provides a method for generating an oligonucleotide with which an exon may be skipped in a pre-mRNA and thus excluded from a produced mRNA thereof. Further provided are methods for altering the secondary structure of an mRNA to interfere with splicing processes and uses of the oligonucleotides and methods in the treatment of disease. Further provided are pharmaceutical compositions and methods and means for inducing skipping of several exons in a pre-mRNA.
114 Citations
3 Claims
- 1. An isolated oligonucleotide of between 20 to 50 nucleotides comprising a sequence consisting of SEQ ID:
Specification