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Reduction in scattering from a turbid medium by photo-bleaching

  • US 7,536,213 B2
  • Filed: 06/15/2007
  • Issued: 05/19/2009
  • Est. Priority Date: 06/16/2006
  • Status: Active Grant
First Claim
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1. A method for reducing elastic scattering from a sample comprising an analyte residing at a significant depth in the sample and a non-uniformly distributed photo-bleachable substance, the method comprising:

  • photo-bleaching the non-uniformly distributed photo-bleachable substance in the sample to induce a reduction in elastic scattering in the sample;

    generating analyte spectra from inelastic scattering from the sample, wherein some or all of the analyte resides at a depth in the sample greater than an effective elastic scattering length of the sample, wherein the effective elastic scattering length is 1/us'"'"', wherein us'"'"' is an isotropic scattering coefficient of the sample, and wherein the inelastic scattering is relatively weak in relation to the elastic scattering; and

    collecting the analyte spectra, wherein a sufficient amount of the analyte resides at the depth in the sample greater than an effective elastic scattering length of the sample such that the collected analyte spectra has a higher signal to noise ratio than without photo-bleaching.

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