Specific binding analysis device
First Claim
Patent Images
1. A specific binding analysis device for performing a qualitative or quantitative analysis of an analyte contained in a sample, said device comprising:
- a first glass capillary tube having;
first and second open ends,a first cavity that includes a detection zone in which a specific binding substance capable of binding an analyte is immobilized, andwherein said first open end serves as an opening portion for applying a sample containing said analyte; and
a second glass capillary tube having;
first and second open ends,a second cavity, andwherein said second glass capillary tube has a smaller cross-sectional area than said first glass capillary tube; and
wherein said second glass capillary tube is inserted into said second end of said first glass capillary tube and an outer surface of said second glass capillary tube is hermetically bonded to an inner surface of said first glass capillary tube; and
wherein said sample applied to said opening portion moves, by capillarity, to said detection zone in said first cavity to cause a specific binding reaction, and a signal attributed to said specific binding reaction is detected to perform a qualitative or quantitative analysis.
2 Assignments
0 Petitions
Accused Products
Abstract
Disclosed is a specific binding analysis method capable of controlling the amount of specific binding to freely setting the sensitivity, concentration range and the like in an analysis, and a device used therefor. In order to optimize the amount of specific binding, the specific binding analysis method and the device used therefor restrain the amount and velocity of a sample passing, by capillarity, through a detection zone, by controlling the dimensions, ventilation resistance, hydrophilicity and the like in the portion of the device where the sample passes through.
23 Citations
6 Claims
-
1. A specific binding analysis device for performing a qualitative or quantitative analysis of an analyte contained in a sample, said device comprising:
-
a first glass capillary tube having; first and second open ends, a first cavity that includes a detection zone in which a specific binding substance capable of binding an analyte is immobilized, and wherein said first open end serves as an opening portion for applying a sample containing said analyte; and a second glass capillary tube having; first and second open ends, a second cavity, and wherein said second glass capillary tube has a smaller cross-sectional area than said first glass capillary tube; and wherein said second glass capillary tube is inserted into said second end of said first glass capillary tube and an outer surface of said second glass capillary tube is hermetically bonded to an inner surface of said first glass capillary tube; and wherein said sample applied to said opening portion moves, by capillarity, to said detection zone in said first cavity to cause a specific binding reaction, and a signal attributed to said specific binding reaction is detected to perform a qualitative or quantitative analysis. - View Dependent Claims (2, 3, 4, 5)
-
-
6. A specific binding analysis device for performing a qualitative or quantitative analysis of an analyte contained in a sample, the device comprising:
-
a first glass capillary tube of uniform inside diameter that includes; a first end for receiving a sample, a second end having an outside surface of a second glass capillary tube hermetically bonded to an inside surface of the first glass capillary tube, and a detection zone having a binding substance immobilized on the inside surface of the first glass capillary tube and capable of binding to the analyte of said sample; wherein the sample applied to the first end of the first glass capillary tube moves by capillarity to the detection zone to cause a specific binding reaction, and wherein a signal attributed to the specific binding reaction is detected to perform a qualitative or quantitative analysis.
-
Specification