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Androgen-regulated PMEPA1 gene and polypeptides

  • US 7,537,896 B2
  • Filed: 06/15/2006
  • Issued: 05/26/2009
  • Est. Priority Date: 01/28/2000
  • Status: Expired due to Fees
First Claim
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1. A method of diagnosing prostate cancer, comprising determining the expression of an androgen-regulated gene in a biological sample comprising prostate cells, wherein the androgen-regulated gene is PMEPA1, wherein expression of the PMEPA1 gene is determined by measuring the level of expression of a PMEPA1 nucleotide sequence comprising SEQ ID NO:

  • 2 in the biological sample, and wherein reduced expression of the PMEPA1 gene in the biological sample as compared to a control sample comprising noncancerous prostate cells correlates with an increased probability for the presence of prostate cancer.

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