Cognitive training using guided eye movements

• US 7,540,615 B2
• Filed: 08/15/2008
• Issued: 06/02/2009
• Est. Priority Date: 12/15/2006
• Status: Active Grant

• Current Assignee: Posit Science Corp.
• Original Assignee: Posit Science Corp.
• Inventors: Merzenich, Michael M., Hardy, Joseph L., Brenner, Donald F., Delahunt, Peter B., Mahncke, Henry W., Lisberger, Stephen G., Bird, Dylan, Chan, Samuel C.
• Primary Examiner(s): Choi; William C
• Assistant Examiner(s): Dinh; Jack
• Application Number:
  US12/192,245
• Publication Number:
  US 20090051877A1
• Time in Patent Office: 291 Days
• Field of Search: 351/203, 351/211, 351237-242, 351/246, 351/223
• US Class Current: 351/246
• CPC Class Codes: G09B 7/04 characterised by modifying the teaching programme in response to a wrong answer, e.g. repeating the question, supplying a further explanation

Abstract

Computer-implemented method for enhancing a participant'"'"'s cognition, including, e.g., visual memory, utilizing a computing device to present visual stimuli for training, and to record responses from the participant. Multiple graphical elements are provided for visual presentation to the participant. A temporal sequence of a plurality of the graphical elements is visually presented, including displaying each graphical element in the sequence at a respective location in a visual field for a specified duration, then ceasing to display the graphical element. The presented graphical elements include at least two matching graphical elements. The participant is required to respond to the presented sequence, including indicating locations of matching graphical elements. A determination is made as to whether the participant responded correctly, and the duration modified based on the determining. The visually presenting, requiring, determining, and modifying are repeated one or more times in an iterative manner to improve the participant'"'"'s cognition.

Claims

1. A method for enhancing cognition in a participant, utilizing a computing device to present visual stimuli for training, and to record responses from the participant, the method comprising:

providing multiple graphical elements, and wherein the multiple graphical elements are available for visual presentation to the participant;

visually presenting a temporal sequence of a plurality of the graphical elements, including displaying each graphical element in the sequence at a respective location in a visual field for a specified duration, then ceasing to display the graphical element, wherein the plurality of the graphical elements includes at least two matching graphical elements;

requiring the participant to respond to the presented sequence, including indicating locations of matching graphical elements;

determining whether the participant responded correctly;

modifying the duration based on said determining; and

repeating said visually presenting, said requiring, said determining, and said modifying one or more times in an iterative manner to improve the participant'"'"'s cognition.

2. The method of claim 1, wherein the plurality of graphical elements comprises the at least two matching graphical elements and one or more distractors, wherein the distractors differ from the matching graphical elements in one or more of:

colors;

patterns; and

/or

shapes.

3. The method of claim 2, wherein said visually presenting, said requiring, and said determining compose performing a trial, and wherein said repeating comprises performing a plurality of trials under each of a plurality of configurations, wherein each configuration specifies one or more attributes of the plurality of graphical elements or their presentation.

4. The method of claim 3, wherein the visual field comprises a plurality of potential stimulus locations, wherein said visually presenting a temporal sequence of a plurality of the graphical elements comprises presenting the graphical elements of the sequence at respective ones of the potential stimulus locations.

5. The method of claim 4, wherein the respective ones of the potential stimulus locations are selected randomly or pseudo-randomly.

6. The method of claim 4, wherein each of the plurality configurations specifies one or more of:

stimulus presentation area, wherein the stimulus presentation area comprises at least a subset of the visual field;

minimum number of potential stimulus locations;

number of graphical elements in the sequence;

number of matching graphical elements in the sequence;

stimulus set, comprising a set of graphical elements from which the plurality of graphical elements of the sequence are selected, wherein the graphical elements of the stimulus set have a specified discriminibility;

gap, comprising a specified amount of time between ceasing display of a graphical element and displaying a next graphical element in the sequence; and

emphasis level, specifying a degree of distinguishability of the presented graphical elements with respect to a background of the visual field.

7. The method of claim 6, wherein said performing a plurality of trials under each of a plurality of configurations comprises one or more of:

co-varying the stimulus presentation area with the minimum number of potential stimulus locations;

or

co-varying the gap with the emphasis level.

8. The method of claim 6, wherein said performing a plurality of trials under each of a plurality of configurations comprises:

performing a plurality of trials under each of a plurality of configurations of varying difficulty.

9. The method of claim 8, wherein said performing a plurality of trials under each of a plurality of configurations of varying difficulty comprises performing a plurality of trials under each of a plurality of increasingly difficult configurations for each of a succession of levels, wherein each level specifies:

a respective visual field layout and background;

a respective emphasis level;

a respective stimulus type corresponding to the emphasis level.

10. The method of claim 4, further comprising:

indicating whether the participant responded correctly, wherein said indicating is performed audibly and/or graphically.

11. The method of claim 10, wherein said indicating whether the participant responded correctly comprises:

for each location indication, indicating whether the indicated location is correct.

12. The method of claim 10, wherein said indicating whether the participant responded correctly comprises one or more of:

presenting a reward in response to the participant responding correctly;

or

presenting a punishment in response to the participant not responding correctly.

13. The method of claim 12, wherein said determining if the participant responded correctly comprises determining that the participant correctly indicated the locations of all matching graphical elements in the sequence, wherein the indicated locations comprise a first indicated location and a last indicated location.

14. The method of claim 13, wherein said presenting a reward in response to the participant responding correctly comprises:

presenting a graphical reward at the last indicated location.

15. The method of claim 13, wherein each potential stimulus location is associated with a respective object, wherein the object is progressable through a plurality of developmental stages, including an initial stage and a final stage, wherein each object comprises an icon indicating a current stage of the respective object and displayed at the potential stimulus location, and wherein said presenting a reward in response to the participant responding correctly comprises:

incrementing the stage for an object associated with the final indicated location, wherein said incrementing comprises displaying the icon indicating the stage of the object.

16. The method of claim 15, wherein when an object associated with a potential stimulus location is at the final stage, graphical elements of a presented sequence are prohibited from being displayed at that potential stimulus location.

17. The method of claim 15, wherein the potential stimulus locations comprise a plurality of groups, each comprising a respective disjoint subset of the potential stimulus locations with their respective objects, the method further comprising:

in response to determining that all objects in a group are at the final stage;

presenting a group reward; and

re-setting all objects in the group to the initial stage, including updating the icons to indicate the initial stage.

18. The method of claim 17, wherein said updating the icons to indicate the initial stage comprises displaying an initial stage icon that indicates said presenting a group reward has occurred.

19. The method of claim 17, the method further comprising:

in response to determining that an object is at the final stage;

incrementing the stage of each other object in the group; and

updating the icons for each incremented object to indicate their respective stages;

performing said incrementing the stage of each other object in the group and said updating in response to each object in the group reaching the final stage due to said incrementing.

20. The method of claim 17, the method further comprising:

in response to determining that no stages for any objects in a group have been incremented for a first specified number of trials;

graphically indicating a first level of stasis for the group.

21. The method of claim 17, the method further comprising:

in response to determining that no stages for any objects in a group have been incremented for a further second specified number of trials;

graphically indicating a second level of stasis for the group; and

decrementing the respective stages of objects in the group that are not at the initial stage.

22. The method of claim 21, the method further comprising:

in response to determining that no stages for any objects in a group have been incremented for a further third specified number of trials;

graphically indicating a next level of stasis for the group; and

decrementing the respective stages of objects in the group that are not at the initial stage.

23. The method of claim 22, the method further comprising:

for each further third specified number of trials in which no stages for any objects in a group have been incremented

graphically indicating a next level of stasis for the group; and

decrementing the respective stages of objects in the group that are not at the initial stage.

24. The method of claim 23, further comprising:

in response to determining that all objects in a group are at the initial stage;

removing the graphical indication of stasis for the group.

25. The method of claim 23, further comprising:

for a group with a stasis level, in response to incrementing the stage of at least one object in the group, resetting the level of stasis of the group to none.

26. The method of claim 23, further comprising:

in response to a configuration wherein the stimulus presentation area is decreased,

for any group with a stasis level in deactivated areas, removing the graphical indication of stasis for the group.

27. The method of claim 17, wherein each group is progressable through multiple group stages, including an initial group stage and a final group stage, wherein said presenting a group reward comprises:

incrementing the group stage of the group, comprising;

for a first group reward for the group, setting the group stage of the group to the initial group stage; and

displaying an icon proximate to the group indicating the group stage of the group.

28. The method of claim 27, the method further comprising:

in response to said incrementing the group stage of the group;

incrementing the stage of objects in all other groups in the stimulus presentation area.

29. The method of claim 27, wherein the icon indicating the group stage of the group comprises a portion of a central object icon, wherein the central reward icon corresponds to a central object, the method further comprising:

in response to a group achieving the final group stage;

presenting a central reward, comprising;

adding the icon indicating the group stage of the group to the central object icon and displaying the central object icon.

30. The method of claim 29, wherein the central object is progressable through multiple central object stages, including an initial central object stage and a final central object stage, wherein said presenting a central reward comprises:

incrementing the central object stage, including;

displaying the central object icon to indicate the central object stage of the central object.

31. The method of claim 30,

wherein said incrementing the central object stage comprises:

for a first central reward for a level, setting the central object stage to the initial central object stage; and

wherein said displaying the central object icon indicating the central object stage of the central object comprises;

for the final central object stage, displaying a complete central object icon for the level.

32. The method of claim 17, wherein at least one of the group rewards comprises a power-up, comprising one or more:

random rewards for a plurality of objects;

presentation of one or more animations;

removal of a distractor from at least one sequence;

repetition of said visually presenting a temporal sequence for at least one sequence;

or

suspension of said ceasing to display the graphical element for at least one sequence.

33. The method of claim 3, wherein said modifying comprises:

adjusting the duration for said visually presenting based on whether the participant responded correctly;

wherein said adjusting is performed using a maximum likelihood procedure.

34. The method as recited in claim 33, wherein the maximum likelihood procedure comprises one or more of:

a QUEST (quick estimation by sequential testing) threshold procedure;

or

a ZEST (zippy estimation by sequential testing) threshold procedure.

35. The method of claim 33, wherein said adjusting the duration comprises:

adjusting the duration to approach and substantially maintain a specified success rate for the participant.

36. The method of claim 35, wherein said adjusting the duration to approach and substantially maintain a specified success rate for the participant is performed for each of the plurality of configurations.

37. The method of claim 35, wherein said adjusting the duration to approach and substantially maintain a specified success rate for the participant uses a single stair maximum likelihood procedure.

38. The method of claim 33, wherein said repeating comprises:

assessing the participant'"'"'s performance a plurality of times during said repeating.

39. The method of claim 38, wherein said assessing the participant'"'"'s performance a plurality of times is performed according to the maximum likelihood procedure.

40. The method of claim 39, wherein said assessing the participant'"'"'s performance a plurality of times is performed using a 2-stair maximum likelihood procedure.

41. The method of claim 33, wherein said adjusting the duration comprises:

if the participant responds correctly, decreasing the duration; and

if the participant responds incorrectly, increasing the duration.

42. The method of claim 3, further comprising:

recording each response of the participant; and

/or

recording whether the participant responded correctly.

43. The method of claim 1, further comprising:

performing trials in one or more practice sessions under each of one or more configurations.

44. The method of claim 1, wherein said repeating is performed a specified number of times each day, for a specified number of days.

45. A computer-readable memory medium that stores program instructions for enhancing cognition in a participant, utilizing a computing device to present visual stimuli for training, and to record responses from the participant, wherein the program instructions are executable by a processor to perform:

providing multiple graphical elements, and wherein the multiple graphical elements are available for visual presentation to the participant;

visually presenting a temporal sequence of a plurality of the graphical elements, including displaying each graphical element in the sequence at a respective location in a visual field for a specified duration, then ceasing to display the graphical element, wherein the plurality of the graphical elements includes at least two matching graphical elements;

requiring the participant to respond to the presented sequence, including indicating locations of matching graphical elements;

determining whether the participant responded correctly;

modifying the duration based on said determining; and

repeating said visually presenting, said requiring, said determining, and said modifying one or more times in an iterative manner to improve the participant'"'"'s cognition.