Ultrafiltration membrane, device, bioartificial organ, and methods
First Claim
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1. An ultrafiltration system comprising:
- a) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5;
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b) a housing containing said membrane, wherein said housing comprises a coating, said coating being biocompatible for in vivo use; and
c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane.
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Abstract
The present invention relates to ultrafiltration. In particular, the present invention provides a compact ultrafiltration device and methods for generating an ultrafiltrate, both of which can be used for a variety of applications, including, but not limited to filtering blood, diagnostic applications, and as a bioreactor.
44 Citations
21 Claims
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1. An ultrafiltration system comprising:
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a) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5;
1;b) a housing containing said membrane, wherein said housing comprises a coating, said coating being biocompatible for in vivo use; and c) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of filtering a biological fluid comprising:
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a) providing an ultrafiltration system comprising i) a membrane comprising micromachined pores having a length and a width, said length being less than 200 microns and said width being less than 200 nanometers, wherein the ratio of said length to said width is at least 5;
1;ii) a housing containing said membrane; and iii) a fluid delivery passageway with a first end and a second end, said first end positioned outside of said housing, said second end positioned to delivery fluid across said membrane; b) connecting said system to a subject'"'"'s vasculture; and c) passing biological fluid from said vasculature through said system to generate filtered biological fluid. - View Dependent Claims (8, 9, 10, 11, 12)
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13. A method of filtering a biological fluid comprising:
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a) providing a bioartificial ultrafiltration device comprising; i) a housing; ii) an inlet port passing through said housing, said inlet port configured to receive a biological fluid; iii) an outlet port passing through said housing, said outlet port configured to return a biological fluid to a subject; iv) a membrane contained in said housing, said membrane comprising micromachined pores; and v) a population of cells attached to said membrane; b) connecting said system to a subject'"'"'s vasculture; and c) passing biological fluid from said vasculature through said device to generate filtered biological fluid. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21)
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Specification