Compounds for use in weight loss and appetite suppression in humans

• US 7,541,356 B2
• Filed: 03/28/2006
• Issued: 06/02/2009
• Est. Priority Date: 04/13/2000
• Status: Expired due to Fees

• Current Assignee: Savanna Health, LLC
• Original Assignee: Seroctin Research & Technologies
• Inventors: Rosenfeld, Mark J., Forsberg, Scott R.
• Primary Examiner(s): Weddington; Kevin E
• Application Number:
  US11/390,738
• Publication Number:
  US 20060166981A1
• Time in Patent Office: 1,162 Days
• Field of Search: 514/230.5, 514/230.8, 514/909, 424/750
• US Class Current: 514/230.5
• CPC Class Codes: C07D 263/58 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
• CPC Class Codes: C07D 265/36 condensed with one six-membered ring

Abstract

Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C₁-C₄ alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

Claims

1. A process for promoting weight loss and/or to suppress appetite in a human by administering an amount of a composition defined as:

2. A process as defined in claim 1, wherein said amount of said composition comprises a daily dosage of between about 5 mcg and about 60 mg.

3. A process as defined in claim 1, wherein said amount of said composition comprises a daily dosage of about 15 mg.

4. A process as defined in claim 1, wherein said composition is obtained from a leafy and/or immature plant part of one or more monocotyledonous plants selected from the group consisting of corn, wheat, barley, rye, oats, rice, sorghum, millet, bamboo, Job'"'"'s Tears, barley-like grasses, and wild grasses.

5. A process as defined in claim 4, wherein said plant part is dried at a temperature in the range of between about 40°

C. and about 45°

C.

6. A process as defined in claim 4, wherein said plant part contains phenols in total amounts greater than 17.0 mg/gm (dry weight).

7. A process as defined in claim 4, wherein said plant part contains combined amounts of 4-hydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid totaling no more than 1.5 mg/gm (dry weight).

8. A process as defined in claim 1, wherein said composition is obtained from an immature corn plant, Zea mays.

9. A process as defined in claim 8, wherein said immature corn plant has been grown to a height between about 45 centimeters and about 122 centimeters.

10. A process as defined in claim 8, wherein said immature corn plant has been grown to a height that does not exceed between about 30 centimeters and about 45 centimeters.

11. A process as defined in claim 8, wherein said immature corn plant has been grown for less than ten weeks after planting.

12. A process as defined in claim 1, wherein said amount of said composition is administered in a manner selected from the group consisting of:

(1) oral administration;

(2) intranasal administration;

(3) transmucosal administration;

(4) parenteral injection;

(5) implant for sustained release; and

(6) transdermal patch.

13. A process for promoting weight loss and/or suppressing appetite and/or treating at least one of fibromyalgia, sleep disorder, mood disorder, hyperglycemia, arthritis, physical or psychological condition caused by stress, or substance addiction in a human by administering an amount of a composition defined as:

14. The process as defined in claim 13, wherein said amount of said composition comprises a daily dosage of about 15 mg.

15. The process as defined in claim 13, wherein said composition is isolated and/or extracted and/or purified from the leafy and/or immature plant part of one or more monocotyledonous plants selected from the group consisting of corn, wheat, barley, rye, oats, rice, sorghum, millet, bamboo, Job'"'"'s Tears, barley-like grasses, and wild grasses.

16. The process as defined in claim 15, wherein said plant part is dried at a temperature in the range of between about 40°

C. and about 45°

C.

17. The process as defined in claim 15, wherein said plant part contains phenols in total amounts greater than 17.0 mg/gm (dry weight).

18. The process as defined in claim 15, wherein said plant part contains combined amounts of 4-hydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid totaling no more than 1.5 mg/gm (dry weight).

19. The process as defined in claim 13, wherein said composition is isolated and/or extracted and/or purified from an immature corn plant, Zea mays.

20. A process as defined in claim 19, wherein said immature corn plant has been grown to a height between about 45 centimeters and about 122 centimeters.

21. A process as defined in claim 19, wherein said immature corn plant has been grown to a height that does not exceed between about 30 centimeters and about 45 centimeters.

22. A process as defined in claim 19, wherein said immature corn plant has been grown for less than ten weeks after planting.

23. The process as defined in claim 13, wherein said amount of said composition is administered in a manner selected from the group consisting of:

(1) oral administration;

(2) intranasal administration;

(3) transmucosal administration;

(4) parenteral injection;

(5) implant for sustained release; and

(6) transdermal patch and wherein the process comprises enhancing mood and!or treating a mental or mood disorder caused by stress.