System and method for noninvasively monitoring conditions of a subject

• US 7,541,602 B2
• Filed: 06/04/2007
• Issued: 06/02/2009
• Est. Priority Date: 06/04/2007
• Status: Active Grant

• Current Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Original Assignee: OrNim Medical, Ltd. (OrNim, Inc.)
• Inventors: Rokni, Michal, Metzger, Yaacov, Pery-Shechter, Revital
• Primary Examiner(s): Vanore; David A.
• Application Number:
  US11/757,698
• Publication Number:
  US 20080296514A1
• Time in Patent Office: 729 Days
• Field of Search: None
• US Class Current: 250/494.1
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0097 by applying acoustic waves and detecting light, i.e. acoustooptic measurements
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 2021/1727 Magnetomodulation
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

A method and system are presented for use in determining one or more parameters of a subject. A region of interest of the subject is irradiated with acoustic tagging radiation, which comprises at least one acoustic tagging beam. At least a portion of the region of interest is irradiated with at least one electromagnetic beam of a predetermined frequency range. Electromagnetic radiation response of the at least portion of the region of interest is detected and measured data indicative thereof is generated. The detected response comprises electromagnetic radiation tagged by the acoustic radiation. This enables processing of the measured data indicative of the detected electromagnetic radiation response to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and outputting data indicative of the at least one determined parameter.

Claims

1. A method for use in determining one or more parameters of a subject, said method comprising;

(a) irradiating a region of interest of the subject with acoustic tagging radiation, the acoustic tagging radiation comprising at least one acoustic tagging beam being a coded continuous acoustic wave in the form of a predetermined function of at least one parameter of the acoustic radiation varying over time during a measurement time interval, said predetermined time function having a narrow autocorrelation;

(b) irradiating at least a portion of the region of interest with at least one electromagnetic beam of a predetermined frequency range;

(c) detecting an electromagnetic radiation response of said at least portion of the region of interest and generating data indicative thereof, said response comprising electromagnetic radiation tagged by the acoustic radiation, thereby enabling processing said data indicative of the detected electromagnetic radiation response, to determine at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation, and output data indicative of the at least one determined parameter.

2. The method according to claim 1, wherein said continuous acoustic wave is coded by modulating said at least one wave parameter selected from the following:

phase, amplitude, frequency, frequency gradient, phase jump, duty cycle, chirp gradient.

3. The method according to claim 1, wherein said continuous acoustic wave is coded by modulating its phase.

4. The method according to claim 3, wherein the phase modulated continuous acoustic wave is generated as a sequence of pulses having equal or not values of at least one of the following parameters:

duration, amplitude, frequency, frequency gradient, phase jump, duty cycle and chirp gradient.

5. The method according to claim 1, wherein said acoustic tagging beam is produced by operating an acoustic transducer with at least one coding signal in the form of an arbitrary sequence to thereby modulate output of the acoustic transducer in at least one of frequency, phase and amplitude parametric domains.

6. The method according to claim 5, wherein said arbitrary sequence is a pseudo random sequence with a narrow autocorrelation.

7. The method according to claim 5, wherein said at least one coding signal includes at least one of Barker and Golay codes.

8. The method according to claim 5, wherein said at least one coding signal includes short pulses of high amplitude and separation periods of low amplitude.

9. The method according to claim 8, wherein the separations periods are selected such that the phase of light propagating through the media during each pulse is uncorrelated to the phase of light propagating through the media during the timely adjacent pulses.

10. The method according to claim 1, comprising processing said data indicative of the detected electromagnetic response by cross-correlating said data with either said coded signal or a function of said coded signal.

11. The method according to claim 10, wherein the cross correlation is performed at different time delays from a start of the acoustic wave generation.

12. The method according to claim 11, wherein the cross correlation at each delay corresponds to intensity of the tagged light in the detected response corresponding to a distance from the acoustic transducer equal to a product of a speed of acoustic signal propagation in the subject'"'"'s medium and the delay time.

13. The method according to claim 1, comprising processing the data indicative of the detected response, said processing comprising:

correlating said data against an arbitrary sequence, used for modulating output of an acoustic transducer, or against a function of the arbitrary sequence, at different time delays from a start of the acoustic wave generation, and processing the correlated signal to search for a phase shift that gives best correlation for each delay.

14. The method according to claim 13, wherein said processing comprises correlating the data indicative of the detected response with a complex phasor representation of the acoustic sequence and taking an absolute value of the resulting phasor.

15. The method according to claim 1, comprising irradiating the region of interest with a plurality of the coded continuous acoustic waves.

16. The method according to claim 15, wherein the coding signals are in the form of arbitrary sequences corresponding to the coded continuous acoustic waves, respectively, having a near zero cross correlation at any time delay longer than a predetermined time delay.

17. The method according to claim 15, wherein the plurality of said continuous acoustic waves are directed towards the region of interest so as to constructively and/or destructively interfere in at least a part thereof thereby controlling the acoustic radiation power in a volume defined by said at least part of the region of interest.

18. The method according to claim 12, comprising determining optical properties of the region of interest at different distances from the acoustic transducer using the cross correlation.

19. The method according to claim 18, wherein an amplitude of the cross correlation at each delay CCA(τ

,λ

) is determined as a product of light distribution for wavelength λ

at the corresponding distance z and an amplitude of the acoustic wave (PA(τ

)) at said distance.

20. The method according to claim 19, comprising determining the light distribution eliminating contribution of the acoustic wave distribution to the amplitude of the cross correlation, and determining the optical properties by fitting the light distribution to an expected distribution.

21. The method according to claim 18, comprising using the cross correlation for determination of at least one of the following parameters:

oxygen saturation level;

total hemoglobin content; and

blood flow.

22. The method according to claim 21, wherein the oxygen saturation is determined by calculating the spatial gradient of the logarithm of the ratio of two light distributions obtained by detecting the light illuminating the tissue at two different illuminating wavelengths;

repeating said calculation by detecting the light illuminating the tissue at two different wavelengths, at least one wavelength being different from said two illuminating wavelengths; and

determining the oxygen saturation by mapping the two calculations to known theoretical or empirical calculations of blood oxygen saturation levels.

23. The method according to claim 22, wherein said mapping is done by finding the minimal angle between the measured and theoretical vectors that correspond to said two calculations.

24. The method according to claim 22, wherein the measurement is repeated by more than two pairs of different wavelengths.

25. The method according to claim 21, wherein the blood flow is determined by monitoring at least one of the peak amplitude and noise level of the cross correlation signal for at least one wavelength of light, as a function of time, thereby determining changes in the flow rate, thereby enabling determination of the flow distribution by monitoring said changes as a function of depth.

26. The method according to claim 5, wherein said arbitrary sequence is generated using a random number generator with an essentially long period with respect to a length of a respective segment.

27. A system for use in determining one or more parameters of a subject, the system comprising:

an acoustic unit configured and operable for irradiating a region of interest with acoustic tagging radiation comprising at least one acoustic tagging beam being a coded continuous acoustic wave in the form of a predetermined function of at least one parameter of the acoustic radiation varying over time during a predetermined time interval used for measurements, said predetermined function having narrow autocorrelation;

an optical unit configured and operable for irradiating at least a portion of the region of interest with at least one electromagnetic beam of a predetermined frequency range, detecting an electromagnetic radiation response of said at least portion of the region of interest and generating data indicative thereof, said response comprising electromagnetic radiation tagged by the acoustic radiation, said data being indicative of the at least one parameter of the subject in a region corresponding to the locations in the medium at which the electromagnetic radiation has been tagged by the acoustic radiation.

28. The system according to claim 27, wherein the acoustic unit comprises a single acoustic port for locating it at a certain distance from the region of interest.

29. The system according to claim 27, wherein the acoustic unit comprises a plurality of spaced apart acoustic ports at different locations with respect to the region of interest.

30. The system according to claim 27, wherein the optical unit comprises a plurality of light output ports at different locations with respect to the region of interest.

31. The system according to claim 27, wherein the optical unit comprises a plurality of light input ports at different locations with respect to the region of interest.

32. The system according to claim 27, wherein the acoustic unit has an essentially annular shape, the optical unit comprising at least one light input port and at least light output port accommodated within an annular aperture of the acoustic unit.

33. The system according to claim 27, wherein the acoustic unit has at least one aperture, and the optical unit comprises at least one light input port located within said at least one aperture, and a plurality of light output ports arranged in an essentially circular array around said at least one light input port outside the acoustic unit.

34. The system according to claim 27, wherein the acoustic unit comprises a signal generator and an acoustic transducer arrangement, said signal generator being configured and operable to generate at least one coding signal in the form of an arbitrary sequence to actuate the acoustic transducer arrangement to thereby modulate output of the acoustic transducer arrangement in at least one of frequency, phase and amplitude parametric domains.

35. The system according to claim 34, wherein said arbitrary sequence is a pseudo random sequence with the narrow autocorrelation.

36. The system according to claim 34, wherein said at least one coding signal includes at least one of Barker and Golay codes.

37. The system according to claim 27, comprising a control unit configured and operable to operate the acoustic and optical units and for receiving and analyzing said data indicative of the electromagnetic radiation response to identify the tagged electromagnetic radiation and corresponding locations in the subject.

38. The system according to claim 34, comprising a control unit configured and operable to operate the signal generator and the optical unit, and for receiving and processing said data indicative of the electromagnetic radiation response to identify the tagged electromagnetic radiation and corresponding locations in the subject.

39. The system according to claim 38, wherein the control unit is configured for processing said data indicative of the detected response by cross-correlating said data with said coded signal.

40. The system according to claim 39, wherein the control unit is configured for performing said cross-correlation at different time delays from a start of the acoustic wave generation.

41. The system according to claim 40, wherein the control unit is configured for determining the cross correlation at each delay as intensity of the tagged electromagnetic radiation corresponding to a distance from the acoustic transducer equal to a product of a speed of acoustic signal propagation in the subject'"'"'s medium and the delay time.

42. The system according to claim 38, wherein the control unit is configured for operating the acoustic unit for generating a plurality of said coded continuous acoustic waves.

43. The system according to claim 34, wherein the control unit is configured for operating the acoustic unit for generating a plurality of said coded continuous acoustic waves.

44. The system according to claim 43, the coding signals in the form of arbitrary sequences corresponding to the coded continuous acoustic waves, respectively, having a near zero cross correlation at any time delay longer than a predetermined time delay.

45. The system according to claim 44, wherein the control unit is configured for processing said data indicative of the detected response by cross-correlating each portion of said data corresponding to the respective one of the coded continuous acoustic waves with its respective coded signal.

46. The system according to claim 45, wherein the control unit is configured for determining the cross correlation at different time delays from a predefined time relative to the start of the acoustic wave generation.