System and method for treating an adverse cardiac condition using combined pacing and drug delivery

• US 7,542,798 B2
• Filed: 07/25/2005
• Issued: 06/02/2009
• Est. Priority Date: 12/12/2001
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Girouard, Steven D.
• Primary Examiner(s): Getzow; Scott M
• Application Number:
  US11/188,832
• Publication Number:
  US 20050256543A1
• Time in Patent Office: 1,408 Days
• Field of Search: 607/3, 607 9- 27
• US Class Current: 607/3
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A system and method of treating an adverse cardiac condition, such as cardiac arrhythmia or a non-arrhythmic event, involves producing, by use of a patient actuatable non-implanted activator, an activation signal in response to a patient sensing a perceived adverse cardiac condition. The method further involves confirming, by an implantable medical device provided within the patient, that the patient is experiencing an actual adverse cardiac condition. A perceivable initiating signal instructing the patient or a physician to commence with a drug delivery regimen to treat the actual cardiac adverse condition is generated by the non-implanted activator. In one approach, the implantable medical device operates in a safe mode of pacing during drug treatment of the actual adverse cardiac condition. In another approach, an appropriate pacing, cardioversion or defibrillation regimen is initiated to treat the actual adverse cardiac condition.

Claims

1. A method of safely pacing a patient'"'"'s heart when administering a drug therapy to a patient, the method comprising:

detecting that the patient is experiencing an adverse cardiac condition;

confirming, at least in part by an implantable cardiac management device provided within the patient, that the patient is experiencing an actual adverse cardiac condition;

generating, by a non-implantable portable communications device, a signal instructing the patient or a physician to commence delivery of a drug regimen to treat the actual adverse cardiac condition;

initiating a safe pacing mode by the implantable cardiac management device appropriate for the drug regimen delivered to the patient and the detected adverse cardiac condition; and

continuing the safe pacing mode for at least a period of time during which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

2. The method of claim 1, wherein the drug regimen is delivered to treat the adverse cardiac condition and the safe pacing mode comprises an anti pro-arrhythmia pacing mode that reduces the risk of provoking a new arrhythmia or aggravating a pre-existing arrhythmia during delivery of the drug regimen at doses or plasma concentrations below those considered toxic.

3. The method of claim 1, wherein the drug regimen is delivered to treat the adverse cardiac condition and the safe pacing mode comprises a pacing mode that attempts to maintain proper pacing of the heart during the period of time in which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

4. The method of claim 1, wherein the drug regimen comprises a chemical for treating an atrial arrhythmic cardiac condition, and the safe pacing mode comprises a pacing mode that reduces the risk of a ventricular arrhythmia developing during the period of time in which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

5. The method of claim 1, wherein the drug regimen comprises a chemical for treating a non-arrhythmic cardiac condition, and the safe pacing mode comprises a pacing mode that enhances pumping efficiency of the patient'"'"'s heart during the period of time in which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

6. The method of claim 1, comprising communicating information between the portable communications device and a network communicatively coupled to the portable communications device.

7. The method of claim 1, comprising effecting communication between the implantable cardiac management device and the network via the portable communications device.

8. The method of claim 7, comprising transmitting at least one of instructions, commands, and software changes from the network to the portable communications device.

9. The method of claim 7, comprising transmitting at least one of instructions, commands, and software changes from the network to the implantable cardiac management device via the portable communications device.

10. The method of claim 1, comprising:

communicating information regarding the detected adverse cardiac condition between the implantable cardiac management device and the portable communications device;

communicating information between the portable communications device and a network communicatively coupled to the portable communications device;

transmitting a signal from the network to the portable communications device; and

adjusting operation of the portable communications device in response to the transmitted signal.

11. The method of claim 10, comprising receiving an input from a physician, wherein the signal is generated in response to the physician input.

12. The method of claim 1, comprising:

communicating information regarding the detected adverse cardiac condition between the implantable cardiac management device and the portable communications device;

communicating information between the portable communications device and a network communicatively coupled to the portable communications device;

transmitting a signal from the network to the portable communications device; and

adjusting operation of the implantable cardiac management device in response to the transmitted signal.

13. The method of claim 12, comprising receiving an input from a physician, wherein the signal is generated in response to the physician input.

14. A medical system, comprising:

an implantable cardiac management device comprising;

a communications unit;

a detector configured to detect cardiac electrical activity;

an energy delivery system;

a lead system coupled to the detector and the energy delivery system; and

a control system coupled to the communications unit, the detector, and the energy delivery system, the control system configured to operate in a plurality of energy delivery modes, the plurality of energy delivery modes comprising at least a safe pacing mode; and

a non-implantable portable communications device, comprising;

a housing configured for portability by the patient;

communication circuitry supported by the housing and configured to effect communications with the implantable cardiac management device;

a user interface supported by the housing; and

a controller supported by the housing and coupled to the communication circuitry and the user interface;

wherein the system confirms, at least in part by use of the implantable cardiac management device, that the patient is experiencing an actual adverse cardiac condition, and the portable communications device generates an instruction via the user interface instructing the patient or a physician to commence delivery of a drug regimen to treat the actual adverse cardiac condition, the control system of the implantable cardiac management device initiating a safe pacing mode appropriate for the drug regimen delivered to the patient and the detected adverse cardiac condition and continuing the safe pacing mode for at least a period of time during which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

15. The system of claim 14, wherein the safe pacing mode comprises an anti pro-arrhythmia pacing mode that reduces the risk of provoking a new arrhythmia or aggravating a pre-existing arrhythmia during delivery of the drug regimen at doses or plasma concentrations below those considered toxic.

16. The system of claim 14, wherein the drug regimen comprises a chemical for treating an atrial arrhythmic cardiac condition, and the safe pacing mode comprises a pacing mode that attempts to maintain proper pacing of the heart during the period of time in which the delivered drug regimen that treats the adverse cardiac condition could influence the patient'"'"'s cardiac activity.

17. The system of claim 14, wherein the drug regimen comprises a chemical for treating a non-arrhythmic cardiac condition, and the safe pacing mode comprises a pacing mode that enhances pumping efficiency of the patient'"'"'s heart during the period of time in which the delivered drug regimen could influence the patient'"'"'s cardiac activity.

18. The system of claim 14, wherein the communication circuitry of the portable communications device comprises:

a first communications circuit configured to effect communications with the implantable cardiac management device; and

a second communications circuit configured to effect communications with a network.

19. The system of claim 18, wherein the controller receives information from the network via the second communications circuit, the controller adjusting operation of the portable communications device in response to the received signal.

20. The system of claim 18, wherein the controller receives information from the network via the second communications circuit, the controller adjusting operation of the implantable cardiac management device in response to the received signal.