Glaucoma implant having MEMS flow module with flexing diaphragm for pressure regulation

• US 7,544,176 B2
• Filed: 06/21/2005
• Issued: 06/09/2009
• Est. Priority Date: 06/21/2005
• Status: Expired due to Fees

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Sniegowski, Jeffry J., Rodgers, M. Steven, McWhorter, Paul J.
• Primary Examiner(s): Deak; Leslie R
• Application Number:
  US11/158,144
• Publication Number:
  US 20070004998A1
• Time in Patent Office: 1,449 Days
• Field of Search: 604/4.01, 604/6.09, 604/264, 604/8, 604/9, 604/506, 604/6.1, 604/7, 210/321.84, 210/321.75, 210/511, 210/85, 210/500.22, 210/500.26, 137/115.13, 422/101
• US Class Current: 604/9
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

One embodiment of a MEMS flow module (34) includes a first plate (36) and a second plate (48) that are separated by a first link (62). A plurality of concentrically disposed, annular flow-restricting walls (40) extend from the first plate (36), and each is separated from the second plate (48) by a flow-restricting gap (58). When the MEMS flow module (34) is exposed to a differential pressure and in one configuration, a perimeter (46) of the first plate (36) flexes away from the second plate (48) (and at least generally about where the first link (62) interfaces with the first plate (36)) to increase the size of one or more of the flow-restricting gaps (58), to in turn accommodate an increased flow or flow rate through the MEMS flow module (34).

Claims

1. An implant for addressing pressure within a first body region, said implant comprising:

a conduit comprising a flow path and adapted to fluidly interconnect with the first body region; and

a MEMS flow module associated with said flow path, wherein said MEMS flow module comprises;

a first plate comprising a first flow port;

a second plate comprising a second flow port, wherein said second plate is spaced from and structurally interconnected with said first plate; and

a first flow-restricting structure extending from one of said first and second plates at least toward the other of said first and second plates, wherein a spacing between said first flow-restricting structure and the other of said first and second plates defines a first flow restriction, and wherein at least one dimension of said first flow restriction changes based upon at least one of said first and second plates flexing in response to a development of at least a certain differential pressure across said MEMS flow module;

wherein said first plate comprises a first region and a second region that extends from said first region to a perimeter of said first plate, wherein said second plate comprises a third region and a fourth region that extends from said third region to a perimeter of said second plate, wherein said second region of said first plate comprises a plurality of said first flow ports, wherein said third region of said second plate comprises a plurality of said second flow ports, wherein a first link extends between said first and second plates and interfaces with said first plate within said first region and interfaces with said second plate within said third region, and wherein said fourth region of said second plate is at least substantially maintained in a fixed orientation.

2. The implant of claim 1, the first body region is an anterior chamber of an eye.

3. The implant of claim 1, wherein each of said first and second plates comprises at least one layer, and wherein each said layer has a thickness within a range of about 1 micron to about 3 microns.

4. The implant of claim 1, wherein a flow rate through said MEMS flow module increases based upon said at least one dimension of said first flow restriction changing.

5. The implant of claim 1, wherein said at least one dimension of said first flow restriction changes based upon said at least one of said first and second plates flexing in response to a development of any differential pressure greater than zero across said MEMS flow module.

6. The implant of claim 1 wherein said first region is centrally located in relation to said first plate.

7. The implant of claim 1 wherein said second plate is spaced from said first plate in a first direction, wherein said second region of said first plate flexes relative to said first region of said first plate in a second direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction, and wherein said second direction is opposite of said first direction.

8. The implant of claim 7, wherein an entirety of said second plate is at least substantially maintained in a fixed orientation.

9. The implant of claim 7, wherein said third region of said second plate flexes relative to said fourth region of said second plate and in said second direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction.

10. The implant of claim 7, wherein a first surface of said first plate, that is opposite a second surface of said first plate that faces said second plate, becomes at least generally cup-shaped when said second region of said first plate flexes in said second direction.

11. The implant of claim 1, wherein said second plate is spaced from said first plate in a first direction, wherein said first plate is at least substantially maintained in a fixed orientation, wherein said third region of said second plate flexes relative to said fourth region of said second plate and in a second direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction, and wherein said second direction is opposite of said first direction.

12. The implant of claim 1, wherein said MEMS flow module comprises a first fabrication level comprising said first plate and said first flow-restricting structure, as well as a second fabrication level comprising said second plate, and wherein said first flow-restricting structure extends from said first plate at least toward said second plate.

13. The implant of claim 1, wherein said MEMS flow module comprises a first fabrication level comprising said first plate, as well as a second fabrication level comprising said second plate and said first flow-restricting structure, and wherein said first flow-restricting structure extends from said second plate at least toward said first plate.

14. The implant of claim 1, wherein said perimeter of said first plate is disposed inwardly of said perimeter of said second plate.

15. The implant of claim 1, wherein a projection of said first plate onto said second plate defines a region that encompasses each of said plurality of second flow ports, and wherein an entirety of said perimeter of said second plate is disposed outwardly from said region.

16. The implant of claim 1, wherein said first flow-restricting structure is disposed about said first flow port, extends from said first plate in a direction of said second plate, and remains spaced from said second plate, and wherein at least part of said second flow port is disposed beyond a projection of said first flow-restricting structure onto said second plate.

17. The implant of claim 16, further comprising a plurality of said second flow ports.

18. The implant of claim 16, wherein said second plate is spaced from said first plate in a first direction, wherein said second region of said second plate flexes at least generally in said first direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction.

19. The implant of claim 16, wherein said second plate is spaced from said first plate in a first direction, wherein said second region of said first plate flexes at least generally in a second direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction, wherein said second direction is opposite of said first direction.

20. The implant of claim 16, wherein said MEMS flow module comprises a first fabrication level comprising said first plate and said first flow-restricting structure, as well as a second fabrication level comprising said second plate, and wherein said first flow-restricting structure extends from said first plate at least toward said second plate.

21. The implant of claim 1, wherein said first flow-restricting structure extends from said first plate and terminates prior to reaching said second plate.

22. The implant of claim 1, further comprising a plurality of said first flow-restricting structures, each having a corresponding said first flow restriction.

23. The implant of claim 22, wherein each of said plurality of said first flow-restricting structures is annular, and wherein said plurality of said first flow-restricting structures are concentrically disposed.

24. The implant of claim 22 wherein said second and fourth regions of each of said first and second plates, respectively, is maintained in an at least substantially fixed orientation, wherein at least one said first flow-restricting structure extends from said second or fourth region of said one of said first and second plates, wherein at least one said first flow-restricting structure extends from said first or third region of said one of said first and second plates, wherein each said first flow restriction associated with said second or fourth region of either said first or second plate is of a fixed magnitude, and wherein each said first flow restriction associated with said first or third region of either said first or second plate is adjustable by said flexing.

25. The implant of claim 22, wherein each of said plurality of first flow-restricting structures is annular, and wherein none of said plurality of first flow-restricting structures encompass a common region.

26. The implant of claim 22, said first flow restriction for at least two of said first flow-restricting structures are of a different size after said at least one of said first and second plates flexes in response to said development of said at least a certain differential pressure across said MEMS flow module.

27. The implant of claim 1, wherein said first flow-restricting structure is annular.

28. The implant of claim 1, wherein said first flow-restricting structure is in the form of a solid plug.

29. An implant for addressing pressure within a first body region, said implant comprising:

a conduit comprising a flow path and adapted to fluidly interconnect with the first body region; and

a MEMS flow module associated with said flow path, wherein said MEMS flow module comprises;

a first plate comprising first and second regions, wherein said first region of said first plate is disposed about said second region of said first plate, wherein said first and second regions each comprise a plurality of first flow ports, wherein said first region of said first plate comprises at least one first flow-restricting structure, and wherein said second region of said first plate comprises at least one second flow-restricting structure; and

a second plate comprising first and second regions, wherein said first region of said second plate is disposed about said second region of said second plate, wherein said first and second regions of said second plate each comprise a plurality of second flow ports, wherein each of said first and second flow-restricting structures extends from said first plate at least toward said second plate, wherein a space between each said first and second flow-restricting structure defines first and second flow restrictions, respectively, wherein said first region of each of said first and second plates is maintained in an at least substantially fixed orientation, and wherein said second region of at least one of said first and second plates flexes in response to a development of at least a certain differential pressure across said MEMS flow module to change at least one dimension of at least one said second flow restriction;

wherein the first region of the first plate extends from said second region of the first plate to a perimeter of said first plate, wherein the first region of the second plate from said second region to a perimeter of said second plate, wherein a first link extends between said first and second plates and interfaces with said first plate within said second region of the first plate and interfaces with said second plate within said second region of the second plate, and wherein said first region of said second plate is at least substantially maintained in a fixed orientation.

30. The implant of claim 29 wherein said first flow-restricting structure is disposed within said second region of said one of said first and second plates.

31. The implant of claim 30, wherein said first region of said first plate comprises a plurality of said first flow ports, wherein said first region of said second plate comprises a plurality of said second flow ports, wherein said MEMS flow module further comprises a second flow-restricting structure that extends from one of said first and second plates at least toward the other of said first and second plates, and wherein an at least substantially fixed spacing exists between said second flow-restricting structure and its corresponding said other of said first and second plates.

32. The implant of claim 30, further comprising a plurality of structural interconnects extending between said first and second plates within said first region of each of said first and second plates.

33. The implant of claim 30, further comprising at least one annular wall extending between said first and second plates within said first region of each of said first and second plates.

34. The implant of claim 33, further comprising a plurality of structural interconnects extending between said first and second plates within said first region of each of said first and second plates.

35. The implant of claim 30, wherein said second plate is spaced from said first plate in a first direction, wherein said second region of said second plate flexes at least generally in said first direction in response to said development of said at least a certain differential pressure across said MEMS flow module to change said at least one dimension of said first flow restriction.

36. The implant of claim 35, wherein said second region of said first plate also flexes at least generally in said first direction in response to said development of said at least a certain differential pressure across said MEMS flow module.

37. The implant of claim 36, wherein said MEMS flow module comprises a first fabrication level comprising said first plate and said first flow-restricting structure, as well as a second fabrication level comprising said second plate, and wherein said first flow-restricting structure extends from said first plate at least toward said second plate.

38. The implant of claim 36, wherein said MEMS flow module comprises a first fabrication level comprising said first plate, as well as a second fabrication level comprising said second plate and said first flow-restricting structure, and wherein said first flow-restricting structure extends from said second plate at least toward said first plate.

39. The implant of claim 35, wherein an entirety of said first plate is at least substantially maintained in a fixed orientation.

40. The implant of claim 39, wherein said MEMS flow module comprises a first fabrication level comprising said first plate and said first flow-restricting structure, as well as a second fabrication level comprising said second plate, and wherein said first flow-restricting structure extends from said first plate at least toward said second plate.

41. The implant of claim 39, wherein said MEMS flow module comprises a first fabrication level comprising said first plate, as well as a second fabrication level comprising said second plate and said first flow-restricting structure, and wherein said first flow-restricting structure extends from said second plate at least toward said first plate.

42. The implant of claim 29, wherein all flow between any said first flow port and any said second flow port must pass through at least one said first or second flow restriction.

43. The implant of claim 29, wherein each said first and second flow-restricting structure is annular and concentrically disposed.

44. The implant of claim 29, further comprising a plurality of said first and second flow restricting structures.