Cutaneous administration system
First Claim
1. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
- a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and
a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target;
a main body which supports said container;
a dispensing head which supports said orifice; and
a flexible link which couples together said main body and said dispensing head.
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Accused Products
Abstract
Bioactive agents are cutaneously delivered by a jet dispenser using inkjet technology, such as that used in printing. The dispenser propels precise volumes of bioactive agent toward the skin, where they exert a local or topical effect, or move through the skin for transdermal systemic delivery. Drugs are either delivered directly to the skin, or are introduced into a transdermal patch, which may receive repeated dosages. A controller in the dispenser may control delivery of multiple different drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient, such as those monitored by a sensor in communication with the controller, for example to prevent an overdose. The dispenser may act as an electromechanical patch, capable of long term administration of drugs to the skin, to achieve local or systemic pharmaceutical effects. Administration methods are also provided, along with replacement kits.
84 Citations
51 Claims
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1. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target; a main body which supports said container; a dispensing head which supports said orifice; and a flexible link which couples together said main body and said dispensing head. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target, wherein the spacer comprises a continuous elastomeric seal that selectively substantially seals the dispenser against the target to form a substantially closed chamber when the dispenser is in contact with the target. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough, wherein the container comprises multiple container modules, and at least two of the container modules contain different bioactive substances that combine after ejection to produce a bioactive effect; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target. - View Dependent Claims (36, 37, 38, 39, 40, 41)
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42. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for election therethrough; a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the tarciet during ejection of the bioactive composltion to the target; a bio-sensor which monitors a parameter of a subject and generates a signal in response thereto, wherein the bio-sensor comprises a pulse oximetry device; and a controller which automatically dispenses the bioactive composition from the dispenser orifice in response to said signal. - View Dependent Claims (43, 44, 45, 46)
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47. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target; an optical sensor; and a controller in communication with said sensor; wherein said target changes color following delivery of the bioactive composition, and said optical sensor detects said color change and in response thereto, the controller ceases ejection of said composition.
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48. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target; an optical sensor; and a controller in communication with said sensor; wherein said target changes color following absorption of the bioactive composition, and said optical sensor detects said color change and in response thereto, the controller causes said orifice to eject said composition.
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49. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target an optical sensor; and a controller in communication with said sensor; wherein the container comprises two container modules each containing different bioactive substances, the target has indicia detectable by said optical sensor indicative of one of said different bioactive substances, and the controller causes said orifice to eject said one of said different bioactive substances.
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50. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for ejection therethrough; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target; plural activation devices which may be manually triggered to elect said bioactive composition from the jet dispenser, each activation device bearing a label corresponding to an event, with different dosages of the bioactive composition being ejected from the jet dispenser according to which of the plural activation devices is triggered.
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51. An applicator for cutaneous delivery of a bioactive composition to a cutaneous target, comprising:
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a jet dispenser comprising an orifice and a container which holds and delivers the bioactive composition to said orifice for election therethrough, wherein the jet dispenser contains plural bioactive compositions; and a spacer positioned to elevate the orifice above the cutaneous target such that an air gap is established that extends directly from the dispenser orifice to the cutaneous target, the bioactive composition traveling across the air gap between the dispenser orifice and the target during ejection of the bioactive composition to the target; and plural activation devices which may be manually triggered to eject said bioactive composition from the jet dispenser, with different bioactive compositions being ejected from the jet dispenser according to which of the plural activation devices is triggered.
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Specification