Control of halitosis-generating and other microorganisms in the non-dental upper respiratory tract

• US 7,544,204 B2
• Filed: 02/25/2005
• Issued: 06/09/2009
• Est. Priority Date: 10/15/2003
• Status: Active Grant

• Current Assignee: Valent Medical Incorporated
• Original Assignee: Valam Corp
• Inventors: Krespi, Yosef, Kacker, Ashutosh
• Primary Examiner(s): Leubecker; John P
• Assistant Examiner(s): Chen; Victoria W
• Application Number:
  US11/066,729
• Publication Number:
  US 20060047329A1
• Time in Patent Office: 1,565 Days
• Field of Search: 607 88- 95, 607/134, 151/05, 128/898, 606 88- 94, 606/134
• US Class Current: 607/88
• CPC Class Codes: A61N 1/403 for thermotherapy, e.g. hyperthermia
• CPC Class Codes: A61N 2005/0606 Mouth
• CPC Class Codes: A61N 2005/0607 Nose
• CPC Class Codes: A61N 2005/0644 Handheld applicators
• CPC Class Codes: A61N 2005/0651 Diodes
• CPC Class Codes: A61N 2005/0654 Lamps
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

Disclosed are safe, simple and effective broad-spectrum treatments for halitosis and other microbial infections of the nondental upper respiratory tract useful to treat bacterial and other microorganism species, including anaerobic bacteria. Electromagnetic radiative energy including visible, and optionally, thermal, RF and/or microwave wavelengths, is topically applied to internal surfaces of the upper respiratory tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. One useful apparatus is a handheld energy applicator having a light output head suitable for treating the back of the tongue and the tonsils and which may be interchangeably provided with extensions to reach the sinuses. The energy applicator can be supported and guided by a mounting device held between the subject'"'"'s teeth, if desired. Useful embodiments of the invention include preparative treatment of the target surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. Optionally a pre-treament procedure may be employed to remove detritus and microfloral overgrowths that may mask more deeply resident target microorganisms. Novel treatments include treatment of halitosis by destruction of bacterial species associated with halitosis, such as Atopobium parvulum, by application of non-ionizing radiative energy to the tonsils and the back of the tongue. Another embodiment comprises a candy bar incorporating a halitosis treatment lamp disposed within the candy.

Claims

1. A method for the treatment of halitosis comprising:

determining whether a subject is presenting with a symptom of halitosis by detecting whether oral odor is emanating from the subject;

applying visible light energy to a nondental target site selected from the group consisting of the back of the tongue, a tonsil, multiple tonsils, the throat and the pharynx of a subject presenting with a symptom of halitosis, the target site being determined to harbor a colony of anaerobic microorganisms generating malodorous gas wherein the visible light energy is applied to the target site at a wavelength and an intensity and for a duration effective to control the colony of microorganisms; and

applying to the target site longer wavelength energy comprising heat, RF or microwave energy or combinations of two or more of said energies.

2. A method according to claim 1 wherein the heat energy is provided by an infrared radiative source, a convective source, a conductive source or by in situ induction by RF or microwave energy.

3. A method according to claim 1 wherein the RF energy is in a range of from about 300 kHz to about 100 MHz.

4. A method according to claim 1 wherein the microwave energy has a frequency or frequencies in the range of from about 100 MHz to about 50,000 MHz.

5. A method according to claim 3 wherein the RF energy has an output power of from about 5 to about 200 W, a pulse duration of from about 1 to about 500 msec and a pulse rate of from about 0.1 to about 10 pulses per second.