Medical device with bioactive agent

• US 7,544,207 B2
• Filed: 10/06/2005
• Issued: 06/09/2009
• Est. Priority Date: 10/06/2004
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Case, Brian C., Flagle, Jacob A., Paul, Ram H., Osborne, Thomas A., Obermiller, Joseph F.
• Primary Examiner(s): Isabella; David
• Assistant Examiner(s): Ganesan; Suba
• Application Number:
  US11/244,991
• Publication Number:
  US 20060136044A1
• Time in Patent Office: 1,342 Days
• Field of Search: 623/1.24, 623/1.42, 623 21- 219, 623/916, 623/1.26, 623/1.4, 623/1.41, 623/2.42
• US Class Current: 623/2.16
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2230/0026 trapezoidal
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0095 Saddle-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

Claims

1. A prosthetic valve for selectively permitting fluid flow through a body vessel in a first direction and substantially preventing fluid flow through said body vessel in a second, opposite direction, said prosthetic valve comprising:

a support frame having radially expanded and radially compressed configurations;

a first bioremodellable leaflet attached to the support frame and including a first base portion attached to the support frame and a first free edge that is moveable within said body vessel;

a second bioremodellable leaflet attached to the support frame and including a second base portion attached to the support frame and a second free edge that is moveable within said body vessel; and

an antiproliferative agent associated with at least one of the first and second free edges;

wherein the first and second free edges cooperatively define a valve orifice that opens and closes in response to movement of the first and second free edges; and

wherein the first and second base portions are free of the antiproliferative agent such that remodelling of the at least one free edge with which the antiproliferative agent is associated is delayed with respect to remodelling of the first and second base portions.

2. The prosthetic valve according to claim 1, wherein at least one of the first and second leaflets comprises an edge that at least partially defines an opening for permitting a controlled amount of said fluid flow through said body vessel in said second, opposite direction.

3. The prosthetic valve according to claim 2, wherein the at least one of the first and second leaflets defines a flap capable of substantially covering the opening.

4. The prosthetic valve according to claim 1, wherein the first and second leaflets comprise an extracellular matrix material.

5. The prosthetic valve according to claim 1, wherein the first and second leaflets comprise small intestine submucosa.