Methods for determining intracranial pressure non-invasively
First Claim
1. A method for determining ICP of a subject based on at least two variable inputs, comprising:
- acquiring acoustic data from a target site on a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data;
acquiring, as a second variable input, arterial blood pressure (ABP) data; and
determining ICP based on the first and second variable inputs using a non-linear relationship.
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Abstract
Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship. Methods and systems for locating target areas based on their acoustic properties and for acoustic scanning of an area, identification of a target area of interest based on acoustic properties, and automated focusing of an acoustic source and/or detector on a desired target area are also provided. Acoustic transducer assemblies are described.
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Citations
43 Claims
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1. A method for determining ICP of a subject based on at least two variable inputs, comprising:
- acquiring acoustic data from a target site on a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data;
acquiring, as a second variable input, arterial blood pressure (ABP) data; and
determining ICP based on the first and second variable inputs using a non-linear relationship. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
- acquiring acoustic data from a target site on a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data;
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10. A method for determining ICP of a subject based on at least three variable inputs, comprising:
- acquiring acoustic data from a target site on or in a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data;
acquiring, as a second variable input, arterial blood pressure (ABP) data;
acquiring, as a third variable input, physiological data relating to a physiological property other than blood flow velocity and ABP; and
determining ICP based on the first, second and third variable inputs using a non-linear relationship. - View Dependent Claims (11)
- acquiring acoustic data from a target site on or in a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data;
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29. A method for determining intracranial pressure (ICP) of a subject based on at least two variable inputs, each variable input being acquired using non-invasive techniques, comprising:
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acquiring acoustic data from a first target site on a cranial blood vessel of the subject and using, as a first variable input, the acoustic data or a measurement derived from the acoustic data; acquiring a second variable input relating to one or more acoustic properties of a target CNS site, the second variable input being different from the first variable input and being selected from the group consisting of;
acoustic scatter and changes in acoustic scatter, including values of and changes in amplitude, phase and/or frequency of acoustic signals, values of and changes in length of scattered signals relative to the interrogation signal, values of and changes in the primary and/or other maxima and/or minima amplitudes of an acoustic signal within a cardiac and/or respiratory cycle;
ratios of and changes in the ratios of the maximum and/or minimum amplitude to that of mean or variance or distribution of subsequent signals within a cardiac cycle, values of and changes in temporal or spatial variance of scattered or emitted signals at different times in the same target location and/or at the same time in different target locations, values of and rates of change of endogenous and/or induced tissue displacement or relaxation, acoustic emissions produced by the endogenous and/or induced tissue displacement or relaxation, and combinations thereof; anddetermining ICP based on the first and second variable inputs using a non-linear relationship. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method for determining intracranial pressure (ICP) of a subject based on at least two variable inputs, comprising:
- locating and acoustically illuminating a desired target site in an automated fashion using an array comprising a plurality of acoustic source and/or detector elements by operating the array to acquire acoustic data from numerous sites within a larger target area, selecting at least one localized target site within the target area based on the acoustic data acquired for focused acoustic illumination and/or probing, and focusing the acoustic source and/or detector elements on the at least one selected localized target site and acquiring acoustic data from the at least one selected localized target site;
using the acquired acoustic data from the at least one selected localized target site as a variable input;
acquiring another variable input from acquired acoustic data or from an arterial blood pressure (ABP) measurement; and
determining ICP based on the variable inputs using a non-linear relationship. - View Dependent Claims (40, 41, 42, 43)
- locating and acoustically illuminating a desired target site in an automated fashion using an array comprising a plurality of acoustic source and/or detector elements by operating the array to acquire acoustic data from numerous sites within a larger target area, selecting at least one localized target site within the target area based on the acoustic data acquired for focused acoustic illumination and/or probing, and focusing the acoustic source and/or detector elements on the at least one selected localized target site and acquiring acoustic data from the at least one selected localized target site;
Specification