Triggering mechanism for needle-free injector

• US 7,547,293 B2
• Filed: 10/06/2006
• Issued: 06/16/2009
• Est. Priority Date: 10/06/2006
• Status: Active Grant

• Current Assignee: Inovio Pharmaceuticals, Inc.
• Original Assignee: Bioject Incorporated
• Inventors: Williamson, Daniel E., Beylund, Ryan R.
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US11/539,585
• Publication Number:
  US 20080086079A1
• Time in Patent Office: 984 Days
• Field of Search: 604/181, 604/187, 604/208, 604/218, 604220-222, 604/225, 604/228, 604/230, 604/236, 604/131, 604134-137, 604/143, 604/147, 604 68- 70, 175/321, 267/137
• US Class Current: 604/70
• CPC Class Codes: A61M 2005/3123 having air entrapping or venting means, e.g. purging channels in pistons
• CPC Class Codes: A61M 5/2053 Media being expelled from injector by pressurised fluid or vacuum for infusion A61M5/145, A61M5/155
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/50 having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile retractable needles or needle protectors with means for preventing re-use A61M5/321

Abstract

Needle-free hypodermic jet injection devices having an actuation system to effect an injection from a drug delivery system. The actuation system includes an injection force assembly adapted to transmit a driving force to the drug delivery system. The actuation system further includes a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system. In some embodiments, the device has a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly and a recoil member coupled to the injection force assembly and movable relative to the restriction member. The restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

Claims

1. A needle-free injection device comprising:

a drug delivery system including a nozzle having a drug chamber and an outlet orifice, the drug delivery system adapted to expel a volume of liquid from the drug chamber through the outlet orifice;

an actuation system including;

an injection force assembly adapted to transmit a driving force to the drug delivery system; and

a trigger assembly adapted to alter the actuation system between a plurality of configurations including a fired configuration in which the injection force assembly transmits a driving force to the drug delivery system; and

a recoil restriction system including a restriction member adapted to couple the recoil restriction system to the trigger assembly, and a recoil member coupled to the injection force assembly and movable relative to the restriction member, wherein the restriction member limits movement of the recoil member once the recoil member moves a predetermined distance relative to the restriction member.

2. The device of claim 1, wherein the trigger assembly includes a retaining member adapted to limit activation of the injection force assembly.

3. The device of claim 2, wherein the retaining member includes detents adapted to releasably couple with the injection force assembly.

4. The device of claim 2, wherein the restriction member comprises a beveled edge surrounding an aperture in the retaining member, and the recoil member comprises an elongate tube adapted to pass through the aperture.

5. The device of claim 4, wherein the recoil member further comprises flanges extending from the elongate tube and adapted to engage with the beveled edge.

6. The device of claim 1, wherein the trigger assembly comprises first and second housings adapted to move selectively relative to one another to alter the actuation system between at least two of the plurality of configurations, and a trigger sleeve adapted to limit relative movement between the first and second housings.

7. The device of claim 6, wherein the trigger sleeve includes ratchet teeth adapted to limit relative movement between the first and second housings in a predetermined direction.