Method for reversal of myocardial remodeling with electrical stimulation
First Claim
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1. A method, comprising:
- identifying a stressed region of a patient'"'"'s myocardium;
implanting a pacing device with one or more electrodes including a pacing electrode disposed at a first pacing site in proximity to the stressed region;
programming the pacing device to deliver pacing therapy to the first pacing site in a manner such that the stressed region of the myocardium is excited before other regions of the myocardium in order to subject the stressed region to less mechanical stress when the myocardium contracts;
programming the pacing device to measure the patient'"'"'s exertion level with an accelerometer or minute ventilation sensor; and
,programming the pacing device to alternate between a pulse output sequence that pre-excites the stressed region and a pulse output sequence that does not in accordance with the exertion level measurement such that pre-excitation of the stressed region is discontinued during periods of increased exertion.
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Abstract
A method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
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Citations
18 Claims
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1. A method, comprising:
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identifying a stressed region of a patient'"'"'s myocardium; implanting a pacing device with one or more electrodes including a pacing electrode disposed at a first pacing site in proximity to the stressed region; programming the pacing device to deliver pacing therapy to the first pacing site in a manner such that the stressed region of the myocardium is excited before other regions of the myocardium in order to subject the stressed region to less mechanical stress when the myocardium contracts; programming the pacing device to measure the patient'"'"'s exertion level with an accelerometer or minute ventilation sensor; and
,programming the pacing device to alternate between a pulse output sequence that pre-excites the stressed region and a pulse output sequence that does not in accordance with the exertion level measurement such that pre-excitation of the stressed region is discontinued during periods of increased exertion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification