Method of making a capillary channel

• US 7,550,104 B2
• Filed: 11/09/2004
• Issued: 06/23/2009
• Est. Priority Date: 12/12/2000
• Status: Expired due to Fees

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Wogoman, Frank W., Brenneman, Allen J.
• Primary Examiner(s): Warden; Jill
• Assistant Examiner(s): HYUN, PAUL SANG HWA
• Application Number:
  US10/984,504
• Publication Number:
  US 20050061668A1
• Time in Patent Office: 1,687 Days
• Field of Search: 249/63, 264/239, 264/299, 264/272.11, 264/328.1, 264/271.1, 422/100
• US Class Current: 264/328.1
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0645 Electrodes
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B29C 2045/1477 Removable inserts, e.g. the insert being peeled off after moulding
• CPC Class Codes: B29C 45/14 incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles B29C45/1671 takes precedence
• CPC Class Codes: B29C 45/14065 Positioning or centering articles in the mould
• CPC Class Codes: B29C 45/14639 for obtaining an insulating effect, e.g. for electrical components
• CPC Class Codes: B29C 45/14754 being in movable or releasable engagement with the coating, e.g. bearing assemblies
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 21/03 Cuvette constructions
• CPC Class Codes: G01N 27/4473 by electric means

Abstract

An optical reagent format with a precise capillary channel is made by molding a format on a carrier of a precise predetermined thickness. The carrier includes an insert at least a portion of which is molded in the format. Once the format is made, the insert is detached from the carrier and removed from the format leaving a precisely dimensioned capillary channel with an inlet and vent. A reagent may be applied in the capillary channel and the format used to measure the analyte in a fluid such as blood.

An electrochemical sensor with a capillary channel is formed by placing a sacrificial insert and electrodes on a sensor base and applying plastic material. After the plastic material is cured, the sacrificial is removed leaving a capillary channel in the sensor. The inserts may be removed by a tool including a clamp for clamping and holding each insert stationary and a sliding block to which the sensor is secured.

Claims

1. A method of making an optical reagent format with a capillary gap, the method comprising the acts of:

providing a carrier with an insert, said insert being of a predetermined thickness;

placing said carrier in a mold;

molding a format onto said insert, said format having a first length greater than a first width, said insert having a second length oriented along a plane generally parallel to said first length and a second width oriented along a plane generally parallel to said first width, said second width being at least equal to said first width;

separating said insert from said carrier after molding said format onto said insert; and

removing said insert from said format leaving a capillary gap in said format, said capillary gap open on three sides, said capillary gap capable of sampling a fluid.

2. The method of claim 1 further comprising applying reagent in said capillary gap.

3. The method of claim 1 further comprising sealing one of said open sides of said capillary gap.

4. The method of claim 1 further comprising removing said format from said carrier.

5. The method of claim 1 wherein said format includes a pair of legs, and further compromising forming said capillary gap between a pair of legs of said format.

6. The method of claim 1 wherein said format comprises first and second conical elements, and further comprising forming said capillary gap between said first and second conical elements of said format.

7. A method of making an optical reagent format with a capillary channel, the method comprising the acts of:

providing a carrier of a predetermined thickness;

providing an insert on said carrier, said insert having a first length and a first width;

molding a format onto said insert with a portion of said insert extending out of said format, said format having a second length greater than a second width, said first length oriented along a plane generally parallel to said second length and a first width oriented along a plane generally parallel to said second width, said first width being at least equal to said second width; and

removing said insert from said format to provide a capillary channel having three open sides formed by said insert, said capillary channel extending across said format.

8. The method of claim 7 comprising removing said carrier from said format.

9. The method of claim 7 wherein said insert comprising a material of a melt temperature higher than the melt temperature of the material of said format.

10. The method claim 7 comprising molding said format with a first leg for the application of a light source and a second leg for the application of a light detector, said capillary channel being between said first and second legs.

11. The method of claim 7 comprising molding said format with a first conical member on a first side of said format and a second conical member on a second side of said format with said capillary channel between said first conical member and said second conical member.

12. A method of making a part having a small channel disposed therein, the method comprising the acts of:

providing a carrier with a sacrificial insert;

placing the carrier in a mold;

molding the part onto the sacrificial insert, the part having a first side, a second side and a third side, the sacrificial insert extending beyond the first side, the second side and the third side;

separating the sacrificial insert from the carrier; and

removing the sacrificial insert from the part leaving a small channel in the part, the small channel having a cross-sectional size corresponding to the cross-sectional size of the sacrificial insert, the small channel extending across the part, the small channel having three open sides.

13. The method of claim 12 wherein the sacrificial insert comprises metal.

14. The method of claim 13 wherein the sacrificial insert comprises stainless steel.

15. The method of claim 12 wherein the part comprises a sensor adapted to analyze a liquid sample.

16. The method of claim 12 wherein the small channel is a capillary channel.

17. The method of claim 12 wherein the molding of the part comprises injection molding.

18. The method of claim 12 wherein the sacrificial insert comprises a material having a melt temperature higher than the melt temperature of the material used in molding the part.

19. A method of making parts having small channels disposed therein, the method comprising the acts of:

providing a plurality of carriers, each of the plurality of carriers having a sacrificial insert of the same size;

placing the carriers in a mold;

molding a part onto each sacrificial insert, the part having a first length greater than a first width, the sacrificial insert having a second length oriented along a plane generally parallel to the first length and a second width oriented along a plane generally parallel to the first width, the second width being at least equal to the first width;

separating the sacrificial inserts from the carriers; and

removing the sacrificial inserts from the parts leaving a small channel in each part, each of the small channels being of the same size and thickness with each of the small channels having three open sides.

20. The method of claim 19 wherein the second width is greater than the first width.