Somatostatin antagonists
First Claim
Patent Images
1. A compound of the formula:
- H2-β
-Nal-D-Cys-Tyr-D-Trp-Lys-Val-Cys-(2R,3R-(2-hydroxymethyl)-3-hydroxy)propylamide;
H2-Phe-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;
H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;
H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β
-Nal-NH2;
H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;
H2-D-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;
H2-D-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β
-Nal-NH2;
orH2-Phe-D-Phe-Tyr-D-Trp-Lys-Thr-Phe-Thr-NH2;
or a pharmaceutically acceptable salt thereof.
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Abstract
The invention features somatostatin antagonists having a D-amino acid at the second residue.
14 Citations
1 Claim
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1. A compound of the formula:
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H2-β
-Nal-D-Cys-Tyr-D-Trp-Lys-Val-Cys-(2R,3R-(2-hydroxymethyl)-3-hydroxy)propylamide;H2-Phe-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2; H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β
-Nal-NH2;H2-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;H2-D-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-Thr-NH2;H2-D-β
-Nal-D-Cpa-Tyr-D-Trp-Lys-Val-Phe-β
-Nal-NH2;
orH2-Phe-D-Phe-Tyr-D-Trp-Lys-Thr-Phe-Thr-NH2; or a pharmaceutically acceptable salt thereof.
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Specification
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Current AssigneeAdministrators Of The Tulane Educational Fund (ADMINISTRATORS|DAVID H. COY), Ipsen Pharma Sas (Ipsen Sa)
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Original AssigneeAdministrators Of The Tulane Educational Fund (ADMINISTRATORS|DAVID H. COY), Societe de Conseils de Recherches et d'Applications Scientifiques
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InventorsMurphy, William, Morgan, Barry, Coy, David H.
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Primary Examiner(s)Tsang; Cecilia
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Assistant Examiner(s)AUDET, MAURY A
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Application NumberUS10/712,081Publication NumberTime in Patent Office2,049 DaysField of Search530/311, 530/317, 530/328, 530/329, 514/2US Class Current514/1.1CPC Class CodesC07K 14/6555 at least 1 amino acid in D-...
