Diagnosing peripheral vascular disease by monitoring oxygen saturation changes during an accumulation phase

• US 7,553,285 B2
• Filed: 07/09/2008
• Issued: 06/30/2009
• Est. Priority Date: 05/05/2003
• Status: Expired due to Term

• Current Assignee: ViOptix, Inc.
• Original Assignee: ViOptix, Inc.
• Inventors: Mao, Jimmy Jian-min
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US12/170,278
• Publication Number:
  US 20080269620A1
• Time in Patent Office: 356 Days
• Field of Search: None
• US Class Current: 600/481
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence

Abstract

Peripheral vascular disease is diagnosed through measurements of oxygen saturation. In a specific implementation, peripheral vascular disease is diagnosed based on changes in oxygen saturation in tissue. Ischemia is induced, and measurements of changes in oxygen saturation in tissue are made. Based on changes in oxygen saturation during an accumulation phase, a diagnosis is provided of whether a patient has or does not have peripheral vascular disease.

Claims

1. A method of diagnosing peripheral vascular disease comprising:

measuring oxygen saturation in tissue of a patient during an accumulation phase prior to ischemia;

analyzing the oxygen saturation in the tissue during the accumulation phase; and

diagnosing the patient as having peripheral vascular disease according to changes in the oxygen saturation in the tissue during the accumulation phase.

2. The method of claim 1 wherein the analyzing the oxygen saturation comprises calculating a rate of change of oxygen saturation during the accumulation phase.

3. The method of claim 2 wherein the rate of change is calculated at a midpoint of the accumulation phase.

4. The method of claim 2 wherein the diagnosing the patient comprises determining if the rate of change crosses a threshold.

5. The method of claim 1 wherein the analyzing the oxygen saturation comprises calculating a time for oxygen saturation to reach a specified percentage during the accumulation phase.

6. The method of claim 5 wherein the diagnosing the patient comprises determining if the time for oxygen saturation to reach a specified percentage crosses a threshold.

7. The method of claim 1 wherein the analyzing the oxygen saturation comprises:

calculating a rate of change of oxygen saturation during the accumulation phase; and

calculating a time for oxygen saturation to reach a specified percentage during the accumulation phase.

8. The method of claim 7 wherein the diagnosing the patient comprises determining if the rate of change and the time for oxygen saturation during the accumulation phase cross thresholds.

9. A method comprising:

measuring oxygen saturation of the tissue of the patient during an accumulation phase prior to ischemia; and

diagnosing the patient as having peripheral vascular disease based on changes in the oxygen saturation of the tissue during an accumulation phase before ischemia.

10. The method of claim 9 comprising:

providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured rate of change in the oxygen saturation during an accumulation phase crosses a threshold value.

11. The method of claim 9 comprising

providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured time for the oxygen saturation to cross a percentage value during the accumulation phase exceeds a specific time value.

12. The method of claim 9 comprising:

providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured time, from a starting time value to an ending time value, for the oxygen saturation to cross a percentage value exceeds a specific time value, wherein the ending time is within the accumulation phase.

13. The method of claim 9 comprising:

providing a visual indication of a positive diagnosis of peripheral vascular disease on a display when a measured time, from a starting time value to an ending time value, for the oxygen saturation to cross a percentage value exceeds a specific time value, wherein the starting time is within the accumulation phase.

14. A system for diagnosing peripheral vascular disease comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine changes in oxygen saturation in tissue of a patient and make a diagnosis of peripheral vascular disease based on the oxygen saturation changes during an accumulation phase;

a pressure cuff, attachable to the patient, to cause the accumulation phase in the patient; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease.

15. The system of claim 14 wherein the probe comprises a second detector input and a source output, and a first distance between the first detector input and the source output is different from a second distance between the second detector input and the source output.

16. The system of claim 14 wherein the probe comprises a second detector input, a first source output, and a second source output, and a first distance between the first detector input and the first source output is different from a second distance between the second detector input and the second source output.

17. The system of claim 14 wherein the probe comprises a second detector input, a first source output, and a second source output, and a first distance between the first detector input and the first source output is substantially the same as a second distance between the second detector input and the second source output.

18. A system for diagnosing peripheral vascular disease comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine changes in oxygen saturation in tissue of a patient and make a diagnosis of peripheral vascular disease based on the oxygen saturation changes during an accumulation phase; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease,

wherein the diagnosis of peripheral vascular disease is positive when the computer determines a rate of change in the oxygen saturation crosses a threshold value during the accumulation phase before ischemia.

19. A system for diagnosing peripheral vascular disease comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine changes in oxygen saturation in tissue of a patient and make a diagnosis of peripheral vascular disease based on the oxygen saturation changes during an accumulation phase; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease,

wherein the diagnosis of peripheral vascular disease is positive when a measured time for the oxygen saturation to cross a percentage value during the accumulation phase before ischemia exceeds a specific time value.

20. A system for diagnosing peripheral vascular disease comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine changes in oxygen saturation in tissue of a patient and make a diagnosis of peripheral vascular disease based on the oxygen saturation changes during an accumulation phase; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease,

wherein the diagnosis of peripheral vascular disease is positive when a measured time, from a starting time value to an ending time value, for the oxygen saturation to cross a percentage value exceeds a specific time value, and the ending time is within the accumulation phase before ischemia.

21. A system for diagnosing peripheral vascular disease comprising:

a probe comprising a first detector input;

a computer, coupled to process signals received via the first detector input, to determine changes in oxygen saturation in tissue of a patient and make a diagnosis of peripheral vascular disease based on the oxygen saturation changes during an accumulation phase; and

a display, coupled to the computer, to provide a visual indication of a positive diagnosis of peripheral vascular disease,

wherein the diagnosis of peripheral vascular disease is positive when a measured time, from a starting time value to an ending time value, for the oxygen saturation to cross a percentage value exceeds a specific time value, and the starting time is within the accumulation phase before ischemia.