Real-time monitoring of the state of the autonomous nervous system of a patient
First Claim
1. A method for monitoring the state of the autonomous nervous system of a patient, the method comprising the steps of:
- acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient;
obtaining a second measurement signal in the time domain indicative of a respiration rhythm of the patient;
deriving, based on the second measurement signal, at least one respiration-locked time series of the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient;
utilizing the at least one respiration-locked time series to generate at least one measurement signal indicative of irregularity of respiration modulation in the first measurement signal; and
employing the third measurement signal for obtaining an indication of the state of the autonomous nervous system of the patient.
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Abstract
The invention relates to a method and arrangement for monitoring the state of the autonomous nervous system (ANS) of a patient. A first measurement signal is acquired from a patient, the first measurement signal representing a physiological signal measured from the patient. In order to enable real-time monitoring of the state of the ANS, a second measurement signal indicative of a respiration rhythm of the patient is acquired and at least one indicator signal is generated by means of the first and second measurement signals. The at least one indicator signal may then be used to obtain an indication of the state of the autonomous nervous system of the patient.
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Citations
29 Claims
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1. A method for monitoring the state of the autonomous nervous system of a patient, the method comprising the steps of:
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acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient; obtaining a second measurement signal in the time domain indicative of a respiration rhythm of the patient; deriving, based on the second measurement signal, at least one respiration-locked time series of the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient; utilizing the at least one respiration-locked time series to generate at least one measurement signal indicative of irregularity of respiration modulation in the first measurement signal; and employing the third measurement signal for obtaining an indication of the state of the autonomous nervous system of the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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11. A method for monitoring the state of the autonomous nervous system of a patient, the method comprising the steps of:
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acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient; obtaining a second measurement signal indicative of a respiration rhythm of the patient; and generating, based on the first and second measurement signals, at least one indicator signal for obtaining an indication of the state of the autonomous nervous system of the patient, wherein the generating step includes deriving, based on the second measurement signal, at least one respiration-locked time series of the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient, the difference time series including a predetermined number of difference values for each respiration cycle of the patient, each difference value representing the difference of two signal values that are one respiration cycle apart in the respiration-locked time series of the first measurement signal, wherein the generating step further includes a step of defining a low frequency component of the first measurement signal based on the difference time series, the low frequency component serving as the at least one indicator signal, wherein the defining step further includes summing the difference values, thereby forming a time series representing the low frequency component of the first measurement signal.
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12. A method for monitoring the state of the autonomous nervous system of a patient, the method comprising the steps of:
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acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient; obtaining a second measurement signal indicative of a respiration rhythm of the patient; and generating, based on the first and second measurement signals, at least one indicator signal for obtaining an indication of the state of the autonomous nervous system of the patient, wherein the generating step includes deriving, based on the second measurement signal, at least one respiration-locked time series of the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient, the difference time series including a predetermined number of difference values for each respiration cycle of the patient, each difference value representing the difference of two signal values that are one respiration cycle apart in the respiration-locked time series of the first measurement signal, wherein the generating step further includes a step of defining a low frequency component of the first measurement signal based on the difference time series, the low frequency component serving as the at least one indicator signal, wherein the defining step includes; filtering the difference values to form a time series of filtered difference values; and summing the filtered difference values, thereby forming a time series representing the low frequency component of the first measurement signal.
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24. An arrangement for monitoring the state of the autonomous nervous system of a patient, the arrangement comprising:
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first means for acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient; second means for obtaining a second measurement signal in the time domain indicative of a respiration rhythm of the patient; third means operable to derive, based on the second measurement signal, at least one respiration-locked time series of the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient, wherein the third means generates a third measurement signal based on the at least one respiration-locked time series indicative of irregularity of respiration modulation in the first measurement signal; and fourth means for employing the third measurement signal to obtain an indication of the state of the autonomous nervous system of the patient. - View Dependent Claims (25, 26, 27, 28)
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29. An arrangement for monitoring the state of the autonomous nervous system of a patient, the arrangement comprising:
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first means for acquiring a first measurement signal from a patient, the first measurement signal representing a physiological signal measured from the patient; second means for obtaining a second measurement signal indicative of a respiration rhythm of the patient; third means for generating, by means of the first and second measurement signals, at least one indicator signal for obtaining an indication of the state of the autonomous nervous system of the patient; and a fourth means for deriving, based on the second measurement signal, at least one respiration-locked time series for the first measurement signal, the respiration-locked time series being locked to the respiration rhythm of the patient, wherein the third means is configured to derive a difference time series, the difference time series including a predetermined number of difference values for each respiration cycle, each difference value representing the difference of two signal values, which are one respiration cycle apart in the respiration-locked time series of the first measurement signal, wherein the third means are further configured to filter the difference values for obtaining filtered difference values, to form a time series of the filtered difference values, and to sum the filtered difference values.
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Specification