Hydrophilic coatings for medical implements

• US 7,553,511 B2
• Filed: 11/22/2005
• Issued: 06/30/2009
• Est. Priority Date: 05/01/2002
• Status: Expired due to Fees

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Lifescan Incorporated (Duv Holding Corporation)
• Inventors: Hleong, Koon-Wah
• Primary Examiner(s): Yoon; Tae H
• Application Number:
  US11/285,806
• Publication Number:
  US 20060078587A1
• Time in Patent Office: 1,316 Days
• Field of Search: 523/105, 523/112, 604/317, 427/2.28
• US Class Current: 427/2.28
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: C08L 67/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C08L67/06 takes precedence

Abstract

Compositions, methods, devices and kits utilizing water-based hydrophilic coating formulations on medical implements. The composition for applying a coating comprises a sulfonated polyester, water, and a surface active agent. Methods for coating a medical implement comprise providing an aqueous dispersion comprising sulfonated polyester and surface active agent, contacting the medical implement with the aqueous dispersion, and drying the medical implement. Methods for acquiring a sample of bodily fluid from a patient comprise coating a needle with a sulfonated polyester, penetrating the needle into the patient, and drawing bodily fluid through the needle.

Claims

1. A method for acquiring a sample of bodily fluid from a patient, comprising;

(a) coating a needle with a composition comprising a sulfonated polyester;

(b) penetrating said needle into said patient; and

(c) drawing said bodily fluid through said needle.

2. The method of claim 1 wherein said sulfonated polyester comprises a sulfonated poly(alkylene phthalate).

3. The method of claim 2 wherein said sulfonated polyester comprises a polymeric compound having the structure

4. The method of claim 2 wherein said sulfonated polyester comprises a sulfonated poly(ethylene isophthalate).

5. The method of claim 2 wherein said sulfonated polyester comprises poly(ethylene 4-sodiosulfenyl isophthalate).

10. The method of claim 1 further comprising coating said needle with a surface active agent in the presence of said sulfonated polyester.

11. The method of claim 1, further comprising drying said needle to provide a solid coating thereon.

12. The method of claim 11 wherein said drying comprises heating said needle to a temperature of approximately about 60°

C. and 120°

C.

13. The method of claim 1, wherein said coating is carried out using a composition comprising:

(a) between approximately 0.5 % and approximately 30 % of sulfonated polyester by weight;

(b) between approximately 0.1 % and approximately 5 % of surface active agent by weight; and

(c) between approximately 65 % and approximately 99.4 % of water by weight.

14. The method of claim 13, wherein said coating comprises dipping said needle in said composition.

15. The method of claim 11, wherein said solid coating comprises between approximately 80 % and approximately 98 % weight of said sulfonated polyester, and between approximately 20 % and approximately 2 % by weight of surface active agent.

16. The method of claim 15 wherein said sulfonated polyester comprises a sulfonated poly(alkylene phthalate).

17. The method of claim 16 wherein said sulfonated polyester comprises a sulfonated poly(ethylene isophthalate).

18. The method of claim 17 wherein said sulfonated polyester comprises poly(ethylene 4-sodiosulfenyl isophthalate).

6. A method for forming a hydrophilic coating on a medical implement, comprising:

(a) providing an aqueous disperson comprising sulfonated polyester and surface active agent;

(b) contacting said medical instrument with said aqueous disperson; and

(c) drying said medical implement,

wherein said providing said aqueous dispersion comprises providing a composition comprising;

(a) between approximately 0.5% and approximately 30% of sulfonated polyester by weight;

(b) between approximately 0.1% and approximately 5% of surface active agent by weight; and

(c) between approximately 65% and approximately 99.4% of water by weight.

7. The method of claim 6 wherein drying said medical implement comprises;

heating the coated medical implement at about 60°

C. to about 120°

C.

8. The method of claim 6 wherein said medical implement comprises a lancing implement.

9. The method of claim 8 wherein said lancing comprises a microneedle.