Method and apparatus for in vivo collection of circulating biological components

• US 7,553,625 B2
• Filed: 08/27/2004
• Issued: 06/30/2009
• Est. Priority Date: 12/22/2003
• Status: Active Grant

• Current Assignee: John Wayne Cancer Institute
• Original Assignee: John Wayne Cancer Institute
• Inventors: Taback, Bret, Hoon, David, Shaolian, Samuel
• Primary Examiner(s): Lam; Ann Y
• Application Number:
  US10/927,959
• Publication Number:
  US 20050153379A1
• Time in Patent Office: 1,768 Days
• Field of Search: 436/518, 436523-527, 435/4, 435/6, 435/7.1, 435/287.1, 435/287.2
• US Class Current: 435/6.16
• CPC Class Codes: A61B 5/14503 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/6865 Access ports
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe.

Claims

1. A method for detecting disease, comprising the steps of:

providing a binding agent attraction device;

inserting the device into a body;

introducing a binding agent into the body;

attracting at least a portion of the binding agent to the attraction device; and

assessing the binding agent attracted to the attraction device.