Extended wear ophthalmic lens

• US 7,553,880 B2
• Filed: 12/30/2006
• Issued: 06/30/2009
• Est. Priority Date: 09/06/1994
• Status: Expired due to Fees

• Current Assignee: Novartis Ag
• Original Assignee: CIBA Vision Corporation (Bayer AG)
• Inventors: Hopken, Jens, Court, John, Winterton, Lynn Cook, Ho, Arthur, Lohmann, Dieter, Chabrecek, Peter, Liu, Qin, Riffle, Judy Smith, Papaspiliotopoulos, Eric, Meijs, Gordon Francis, Schindhelm, Klaus, Laycock, Bronwyn Glenice, Domschke, Angelika, Nicolson, Paul Clement, Baron, Richard Carlton, Sweeney, Deborah, Terry, Wilson Leonard Jr., Griesser, Hans Jorge, Vogt, Jurgen
• Primary Examiner(s): Cain; Edward J
• Application Number:
  US11/618,798
• Publication Number:
  US 20070105973A1
• Time in Patent Office: 913 Days
• Field of Search: 523/106
• US Class Current: 523/106
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: B29C 39/42 Casting under special conditions, e.g. vacuum
• CPC Class Codes: B29C 71/00 After-treatment of articles without altering their shape; Apparatus therefor B29C44/56, B29C73/00 take precedence; surface shaping B29C59/00 ; for joined or sealed parts B29C66/03; after-treatment specially adapted for vulcanising tyres B29D30/0633
• CPC Class Codes: B29L 2011/0041 Contact lenses
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/48 Polyethers
• CPC Class Codes: C08G 18/4833 Polyethers containing oxyethylene units
• CPC Class Codes: C08G 18/5015 having fluorine atoms
• CPC Class Codes: C08G 18/61 Polysiloxanes
• CPC Class Codes: C08G 18/63 Block or graft polymers obtained by polymerising compounds having carbon-to-carbon double bonds on to polymers
• CPC Class Codes: C08G 18/672 Esters of acrylic or alkyl acrylic acid having only one group containing active hydrogen
• CPC Class Codes: C08G 18/8116 esters of acrylic or alkylacrylic acid having only one isocyanate or isothiocyanate group
• CPC Class Codes: C08G 18/8175 with esters of acrylic or alkylacrylic acid having only one group containing active hydrogen
• CPC Class Codes: C08L 2666/20 Macromolecular compounds having nitrogen in the main chain according to C08L75/00 - C08L79/00; Derivatives thereof
• CPC Class Codes: C08L 33/00 Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 43/04 Homopolymers or copolymers of monomers containing silicon
• CPC Class Codes: C08L 51/08 grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
• CPC Class Codes: C08L 51/085 on to polysiloxanes
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: G02B 1/043 : Contact lenses

Abstract

An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Claims

1. A silicone hydrogel contact lens comprising a core polymeric material formed from polymerizable materials including:

(a) at least one siloxane-containing macromer or monomer; and

(b) at least one hydrophilic monomer,

the contact lens characterized by having on-eye movement with blinking and producing less than about 10% corneal swelling during a period of continuous wear of 7 days including normal sleep periods.

2. The contact lens of claim 1, wherein the at least one hydrophilic monomer is selected from the group consisting of N,N-dimethylacrylamide, 2-hydroxyethyl methacrylate, N-vinylpyrrolidone, and combinations thereof.

3. The contact lens of claim 1, wherein the polymerizable materials comprise both the siloxane-containing macromer and the siloxane-containing monomer and N,N-dimethylacrylamide as the at least one hydrophilic monomer.

4. The contact lens of claim 3, wherein the siloxane-containing macromer is a polydimethylsiloxane macromer.

5. The contact lens of claim 3, wherein the polymerizable materials comprise a crosslinker.

6. The contact lens of claim 5, wherein the crosslinker is ethyleneglycol dimethylacrylate.

7. The contact lens of claim 5, wherein the polymerizable materials comprise a photoinitiator.

8. The contact lens of claim 1, wherein the contact lens includes a surface that is more hydrophilic than the core polymeric material of the lens.

9. The contact lens of claim 1, wherein the surface properties of the contact lens are altered by a surface treatment process.

10. The contact lens of claim 9, wherein the surface treatment is performed prior to and/or posterior to complete polymerization of the polymerizable materials.

11. The contact lens of claim 9, wherein the surface treatment process comprises a process which causes the polymerizable materials at the surface of the lens to differ from the core.

12. The contact lens of claim 11, wherein the surface treatment process is selected from the group consisting of a coating process, a grafting process, a plasma treating process, an electric charge treating process, and an irradiation process.

13. The contact lens of claim 1, wherein the contact lens is characterized by producing less than about 7% corneal swelling during the period of continuous wear.

14. The contact lens of claim 1, wherein the contact lens is characterized by producing less than about 5% corneal swelling during the period of continuous wear.

15. The contact lens according to claim 5, wherein the contact lens includes a surface that is more hydrophilic than the core polymeric material of the lens.

16. The contact lens according to claim 5, wherein the surface properties of the contact lens are altered by a surface treatment process.

17. The contact lens of claim 16, wherein the surface treatment is performed prior to and/or posterior to complete polymerization of the polymerizable materials.

18. The contact lens of claim 16, wherein the surface treatment process comprises a process which causes the polymerizable materials at the surface of the lens to differ from the core.

19. The contact lens of claim 18, wherein the surface treatment is selected from the group consisting of a coating process, a grafting process, a plasma treating process, an electric charge treating process, and an irradiation process.

20. The contact lens of claim 5, wherein the contact lens is characterized by producing less than about 7% corneal swelling during the period of continuous wear.

21. The contact lens of claim 5, wherein the contact lens is characterized by producing less than about 5% corneal swelling during the period of continuous wear.