Array and method for dosing a hormone regulating blood sugar in a patient

• US 7,556,613 B2
• Filed: 01/20/2001
• Issued: 07/07/2009
• Est. Priority Date: 02/10/2000
• Status: Expired due to Term

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Rinne, Helmut, Wittmann, Uwe, Gessler, Ralf, Pfleiderer, Hans-Joerg
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): Mehta; Bhisma
• Application Number:
  US10/203,673
• Publication Number:
  US 20030104982A1
• Time in Patent Office: 3,090 Days
• Field of Search: 604/29, 604/30, 604/65, 604/66, 604/67, 604/131, 604/151, 604/890.1
• US Class Current: 604/65
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/62 Posture
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (10). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device (16) to detect measured values correlatable with blood sugar; b) a controlling means (12) comprising a controller (44) and a hormone dosing device (46) for supplying a hormone dosage; c) a pilot control device (14) acting on the hormone fine dosage controlling means (12) for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.

Claims

1. Array for dosing a hormone suitable for regulating blood glucose of a patient comprising:

a) a measuring device for detecting measured values correlatable with the blood glucose;

b) controlling means comprising a controller to process the measured values according to a control algorithm and a hormone dosing unit to administer a hormone dose;

c) a pilot control device acting on the controlling means to reduce dead time of the controlling means, characterized in that the pilot control device comprises a sensor and has a pre-controlling action on the controlling means in accordance with at least one influencing variable that is detected by the sensor and the sensor is an activity measuring unit for the sensory detection of a degree of physical activity of the patient.

2. Array of claim 1 wherein the pilot control device has a position sensor to detect resting states of the patient.

3. Array as claimed in claim 1, characterized in that the pilot control device has a sensor to detect body parameters of the patient.

4. Array as claimed in claim 1, characterized in that the pilot control device has a basal control element for continuous pre-administration of a basal dose of the hormone.

5. Array of claim 1, characterized in that the pilot control device has a timer.

6. Array as claimed in claim 5, characterized in that the timer is formed for the time-dependent determination of a basal hormone dose.

7. Array as claimed in claim 5, characterized in that the timer is formed for the determination of the time for the administration of hormone boli.

8. Array as claimed in claim 1, characterized in that the pilot control device has a set-point output connected to the controller in order to pre-set a command variable.

9. Array of claim 1, characterized in that the pilot control device and the controller are connected on an output side via a summation element to the hormone dosing unit.

10. Array as claimed in claim 1, characterized in that the pilot control device has means for selecting the control algorithm or to pre-set parameters of the controller.

11. Array as claimed in claim 1, characterized in that the pilot control device has a monitoring stage to monitor and limit the hormone dose.

12. Array as claimed in claim 11, characterized in that the monitoring stage is formed to limit the hormone dose after registering critical conditions of the patient.

13. Array of claim 1, characterized in that the controller is a state controller in which the control algorithm has a program routine acting as observer of the measured values and hormone dosage values in order to estimate non-measurable variables of state.

14. Array of claim 1, characterized in that the controller has a proportional-integral element to deal with disturbance values.

15. Array as claimed in claim 1, characterized in that the hormone dosing unit comprises a dosage pump designed for subcutaneous hormone infusion as the actuator of the controlling means.

16. Array of claim 1 wherein the pilot control device has mercury switches.

17. Array of claim 1 wherein the pilot control device has spirit levels.

18. Array of claim 1, wherein the sensor comprises at least two individual sensors, each of which measures a different influencing variable selected from position, movement, heart rate, body temperature and skin conductivity of the patient.

19. Array for dosing a hormone suitable for regulating blood glucose of a patient comprising:

a) a measuring device for detecting measured values correlatable with the blood glucose;

b) controlling means comprising a controller to process the measured values according to a control algorithm and a hormone dosing unit to administer a hormone dose;

c) a pilot control device acting on the controlling means to reduce dead time of the controlling means, characterized in that the pilot control device has a movement sensor to detect movement states of the patient, wherein the movement sensor is a pedometer.

20. Array for dosing a hormone suitable for regulating blood glucose of a patient comprising:

a) a measuring device for detecting measured values correlatable with the blood glucose;

b) controlling means comprising a controller to process the measured values according to a control algorithm and a hormone dosing unit to administer a hormone dose;

c) a pilot control device acting on the controlling means to reduce dead time of the controlling means, characterized in that the pilot control device has a sensor to detect body parameters of the patient and the sensor detects a heart-rate.

21. Array for dosing a hormone suitable for regulating blood glucose of a patient comprising:

a) a measuring device for detecting measured values correlatable with the blood glucose;

b) controlling means comprising a controller to process the measured values according to a control algorithm and a hormone dosing unit to administer a hormone dose;

c) a pilot control device acting on the controlling means to reduce dead time of the controlling means, characterized in that the pilot control device has a sensor to detect body parameters of the patient and the sensor detects skin conductivity.

22. Array for dosing a hormone suitable for regulating blood glucose of a patient comprising:

a) a measuring device having a glucose sensor for detecting tissue glucose values as measured values correlatable with the blood glucose;

b) controlling means comprising a controller to process the measured values according to a control algorithm and a hormone dosing unit to administer a hormone dose;

c) a pilot control device comprising a second sensor, the pilot control device acting on the controlling means to reduce dead time of the controlling means, characterized in that the pilot control device has a pre-controlling action on the controlling means in accordance with at least one influencing variable that is detected by the second sensor, wherein the pilot control device has a basal control element for continuous pre-administration of a basal dose of the hormone and the basal control element has a correction stage to adjust the basal dose to diurnal variations of a hormone sensitivity of the patient, further wherein the pilot control device has an activity measuring unit for sensory detection of a degree of physical activity of the patient and the basal control element is connected downstream of the activity measuring unit.