3-D interconnected multi-layer microstructure of thermoplastic materials

• US 7,557,051 B2
• Filed: 03/11/2005
• Issued: 07/07/2009
• Est. Priority Date: 03/17/2004
• Status: Expired due to Fees

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Ryu, WonHyoung, Bai, Seoung Jai, Hammerick, Kyle, Greco, Ralph S., Smith, Robert Lane, Prinz, Friedrich B., Fasching, Rainer J.
• Primary Examiner(s): MALSAWMA, LARINFAMKIMA HMAR
• Application Number:
  US11/078,907
• Publication Number:
  US 20050206048A1
• Time in Patent Office: 1,579 Days
• Field of Search: 438/800, 264/328.16
• US Class Current: 438/800
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: B29C 2043/025 forming a microstructure, i.e. fine patterning
• CPC Class Codes: B29C 2043/463 corrugated, patterned or embossed surface
• CPC Class Codes: B29C 2043/5883 ensuring cavity filling, e.g. providing overflow means
• CPC Class Codes: B29C 2059/023 Microembossing
• CPC Class Codes: B29C 33/0033 constructed for making articles provided with holes
• CPC Class Codes: B29C 33/424 Moulding surfaces provided with means for marking or patterning for injection moulding B29C45/372
• CPC Class Codes: B29C 43/003 characterised by the choice of material
• CPC Class Codes: B29C 43/021 characterised by the shape of the surface
• CPC Class Codes: B29C 59/02 by mechanical means, e.g. pressing B29C59/007 takes precedence; embossing expanded porous articles B29C44/5627
• CPC Class Codes: B29C 59/022 characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
• CPC Class Codes: B29C 59/04 using rollers or endless belts
• CPC Class Codes: B29L 2031/7532 Artificial members, protheses

Abstract

Methods for compression molding through holes in polymer layers are provided, as are the resulting patterned polymer layers. Two key aspects of the invention are provision of a mold and substrate having different mechanical hardness, and provision of room for local flow of material. These aspects of the invention facilitate formation of through holes by compression molding that are not blocked or partially blocked by undesirable material. These polymer layers can be formed into three dimensional patterned structures by bonding patterned layers together. Since the layers include through holes, a three-dimensional polymer pattern can be formed. These patterned polymer layers and three dimensionally patterned polymer constructs have a wide variety of applications. For example, these constructs can be used for fabrication of micro-fluidic devices, and/or can be used for various medical and biological applications including drug delivery devices and tissue engineering devices.

Claims

1. A method of fabricating a patterned polymer layer, the method comprising:

a) positioning said polymer layer between a patterned mold and a substrate, wherein said mold and said substrate have substantially different hardnesses, and wherein said polymer layer has a thickness T;

b) compression molding a pattern having at least one through hole into said polymer layer by pressing said mold and said substrate together;

wherein said mold together with said substrate comprises a plurality of unit cells, each having a cell area A, a cell volume V, an occupied cell volume V_oc and an unoccupied cell volume equal to V−

V_oc;

wherein substantially all of a surface of said mold facing said polymer layer is included in said unit cells, and wherein none of said unit cells includes two or more through hole features;

wherein a condition A*T≦

V−

V_oc holds for each of said unit cells;

whereby room for local flow of said polymer during said compression molding is provided.

2. The method of claim 1, wherein said mold comprises a feature for forming said at least one through hole or for forming a blind hole, and wherein said feature has a cross section selected from the group consisting of square, rectangular, circular, and elliptical cross sections.

3. The method of claim 1, wherein said mold comprises a feature for forming said at least one through hole, and wherein said feature comprises a flat top, a conical top, a tapered top section with a flat top surface, or a tapered top section having a sharp outer edge.

4. The method of claim 1, wherein said compression molding is performed at a temperature above a glass transition temperature of said polymer and below a melting temperature of said polymer.

5. The method of claim 1, wherein said mold is harder than said substrate.

6. The method of claim 1, wherein said mold and said substrate are disposed on substantially planar supporting surfaces.

7. The method of claim 1, wherein said mold and said substrate are disposed on substantially cylindrical supporting surfaces.

8. The method of claim 1, further comprising incorporation of one or more inclusions within said pattern.

9. The method of claim 8, wherein said inclusions comprise a bio-active material, one or more bio-active devices, a non bio-active material, or one or more non bio-active devices.

10. The method of claim 1, further comprising treating said mold with a low surface energy surfactant, whereby release of said polymer from said mold is facilitated.

11. The method of claim 1, wherein said mold comprises a lithographically patterned Silicon structure, a micro-patterned metal structure, or a micro-patterned polymer structure.

12. The method of claim 1, further comprising providing electrical connections to features of said pattern.

13. A polymer layer having a pattern provided according to the method of claim 1.

14. The polymer layer of claim 13, wherein said at least one through hole is a tapered through hole.

15. The polymer layer of claim 13, wherein said at least one through hole has a lateral feature size of less than about 100 μ

m.

16. The polymer layer of claim 13, wherein said pattern includes at least one blind hole in addition to said at least one through hole.

17. The polymer layer of claim 16, wherein said blind hole has a cross section selected from the group consisting of square, rectangular, circular and elliptical cross sections.

18. The polymer layer of claim 13, wherein said thickness T is in a range from about 1 μ

m to about 200 μ

m.

19. The polymer layer of claim 13, wherein said polymer comprises a polymer selected from the group consisting of:

biodegradable polymers;

thermoplastic polymers;

polylactides;

polyglycolides;

poly methyl methacrylates;

aliphatic poly ester;

poly-caprolactone;

poly-anhydrides;

poly ortho esters;

alkaly derivatives of Trimethylenecarbonate;

δ

-valerolactone;

β

-butyrolactone;

γ

-butyrolactone;

ε

-decalactone;

hydrocybutyrate;

hydroxyvalerate;

1,4-dioxepan-2-one;

1,5,8,12-tetraoxacyclotetradecane-7,14-dione;

1,5-dioxepan-2-one;

6,6-dimethyl-1,4-diocan-2-one; and

mixtures or co-polymers thereof.

20. The polymer layer of claim 13, wherein said pattern has a density of through holes in a range from about 1/mm² to about 40,000/mm².

21. A method of fabricating a three-dimensionally patterned polymer structure, the method comprising:

a) fabricating a plurality of patterned polymer layers according to the method of claim 1; and

b) bonding said plurality of polymer layers together to form a three-dimensional pattern in said three-dimensional structure.

22. The method of claim 21, wherein said bonding comprises solvent bonding, solvent vapor bonding, flash thermal bonding, adhesive bonding, mechanical interlock bonding, plasma bonding or ultrasonic bonding.

23. The method of claim 21, wherein a gradient of micro-structures in said pattern is established within said three-dimensional structure.

24. The method of claim 23, wherein said gradient is parallel to or perpendicular to a plane of said layers.

25. The method of claim 21, further comprising incorporation of one or more inclusions within said three-dimensional pattern.

26. The method of claim 25, wherein said inclusions comprise a bio-active material, one or more bio-active devices, a non bio-active material, or one or more non bio-active devices.

27. The method of claim 26, wherein a gradient of said inclusions is established within said three-dimensional structure.

28. The method of claim 27, wherein said gradient is parallel to or perpendicular to a plane of said layers.

29. The method of claim 21, further comprising registering said patterned polymer layers precisely to each other.

30. A polymer structure having a three-dimensional pattern provided according to the method of claim 21.

31. The polymer structure of claim 30, wherein said structure comprises a micro-fluidic device, a drug delivery device, or a tissue engineering device.