Stoichiometric conjugates of biocompatible polymers at the unpaired cysteine residue of the wild-type G-CSF
First Claim
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1. A conjugate of a biocompatible polymer and wild type G-CSF, wherein the activated biocompatible polymer is bonded to wild type G-CSF at a 1:
- 1 molar ratio through a thiol group of a cysteine residue free of disulfide bonds corresponding to the position 17 (C17) of the mature human wild-type G-CSF.
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Abstract
The present invention relates to a conjugate of a biocompatible polymer and a G-CSF bonded through a thiol group of a dysteine residue in G-CSF at a 1:1 molar ratio, and methods of preparation thereof.
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10 Claims
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1. A conjugate of a biocompatible polymer and wild type G-CSF, wherein the activated biocompatible polymer is bonded to wild type G-CSF at a 1:
- 1 molar ratio through a thiol group of a cysteine residue free of disulfide bonds corresponding to the position 17 (C17) of the mature human wild-type G-CSF.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A conjugate of a biocompatible polymer and wild type G-CSF that has a methionine residue at position 1, wherein the activated biocompatible polymer is bonded to wild type G-CSF at a 1:
- 1 molar ratio through a thiol group of a cysteine residue free of disulfide bonds corresponding to the position 17 (C17) of the mature human wild-type G-CSF.
Specification