Multiparameter whole blood monitor and method
First Claim
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1. A blood monitoring device comprising:
- an intravascular catheter terminating in a tip;
a transducer configured to transmit an ultrasound signal, wherein the transducer is disposed in the intravascular catheter;
a reflector disposed in the tip of the intravascular catheter and spaced apart a fixed distance from the transducer, wherein the transducer is configured to detect at least a portion of the ultrasound signal that is reflected from the reflector;
an analysis device configured to continuously estimate at least one of a real-time hematocrit value and a real-time hemoglobin value based on a transit time of the ultrasound signal between the transducer and the reflector;
wherein the analysis device includes an attenuation adjustment module configured to measure attenuation of the ultrasound signal, wherein the analysis device is configured to adjust at least one of the estimated real-time hematocrit value and the estimated real-time hemoglobin value based on attenuation of the ultrasound signal measured by the attenuation adjustment module; and
wherein the analysis device includes a backscatter adjustment module configured to measure backscatter of the ultrasound signal, wherein the analysis device is configured to adjust at least one of the estimated real-time hematocrit value and the real-time hemoglobin value based on backscatter measured by the backscatter adjustment module.
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Abstract
The present invention provides an apparatus and methods for continuous intravascular measurement of whole blood concentration, blood pressure, and pulse pressure. The intravascular catheter incorporates a sensor to measure whole blood sound velocity, attenuation, backscatter amplitude, and blood flow velocity and also incorporates existing technologies for multiple physiologic measurements of whole blood. Pulse wave velocity and wave intensity are derived mathematically for purposes of estimating degree of local vascular tone.
93 Citations
21 Claims
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1. A blood monitoring device comprising:
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an intravascular catheter terminating in a tip; a transducer configured to transmit an ultrasound signal, wherein the transducer is disposed in the intravascular catheter; a reflector disposed in the tip of the intravascular catheter and spaced apart a fixed distance from the transducer, wherein the transducer is configured to detect at least a portion of the ultrasound signal that is reflected from the reflector; an analysis device configured to continuously estimate at least one of a real-time hematocrit value and a real-time hemoglobin value based on a transit time of the ultrasound signal between the transducer and the reflector; wherein the analysis device includes an attenuation adjustment module configured to measure attenuation of the ultrasound signal, wherein the analysis device is configured to adjust at least one of the estimated real-time hematocrit value and the estimated real-time hemoglobin value based on attenuation of the ultrasound signal measured by the attenuation adjustment module; and wherein the analysis device includes a backscatter adjustment module configured to measure backscatter of the ultrasound signal, wherein the analysis device is configured to adjust at least one of the estimated real-time hematocrit value and the real-time hemoglobin value based on backscatter measured by the backscatter adjustment module. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A blood monitoring device comprising:
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an intravascular catheter; transit time detection means for generating a signal indicative of a transit time of an ultrasound wave propagating through blood flowing between a first location and a second location, wherein the transit time detection means is at least partially disposed within the intravascular catheter; estimating means for estimating a real-time H/H value responsive to the transit time detection means; backscatter adjustment means for adjusting the estimated real-time H/H value based on backscatter of the ultrasound wave; and attenuation adjustment means for adjusting the estimated real-time H/H value based on attenuation of the ultrasound wave. - View Dependent Claims (9, 10)
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11. The A blood monitoring device comprising
an intravascular catheter terminating in a tip; -
a transducer configured to transmit an ultrasound signal, wherein the transducer is disposed in the intravascular catheter; a reflector disposed in the tip of the intravascular catheter and spaced apart a fixed distance from the transducer, wherein the transducer is configured to detect at least a portion of the ultrasound signal that is reflected from the reflector; an analysis device configured to continuously estimate at least one of a real-time hematocrit value and a real-time hemoglobin value based on a transit time of the ultrasound signal between the transducer and the reflector; wherein the analysis device includes an attenuation adjustment module configured to measure attenuation of the ultrasound signal, wherein the analysis device is configured to adjust at least one of the estimated real-time hematocrit value and the estimated real-time hemoglobin value based on attenuation of the ultrasound signal measured by the attenuation adjustment module; and wherein the analysis device is configured to calculate a plasma protein value based on an attenuation measured by the attenuation adjustment module. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification