Conversion of nitrogen dioxide (NO2) to nitric oxide (NO)
First Claim
1. An apparatus for converting nitrogen dioxide to nitric oxide comprising a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow comprising nitrogen dioxide and fluidly communicate the gas flow to the outlet through the surface-active material such that the surface-active material reacts with nitrogen dioxide in the gas flow and converts the nitrogen dioxide to nitric oxide.
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Reexamination
Accused Products
Abstract
Inhalation of low levels of nitric oxide can rapidly and safely decrease pulmonary hypertension in mammals. A nitric oxide delivery system that converts nitrogen dioxide to nitric oxide employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid.
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Citations
28 Claims
- 1. An apparatus for converting nitrogen dioxide to nitric oxide comprising a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive a gas flow comprising nitrogen dioxide and fluidly communicate the gas flow to the outlet through the surface-active material such that the surface-active material reacts with nitrogen dioxide in the gas flow and converts the nitrogen dioxide to nitric oxide.
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16. An apparatus for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:
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a permeation cell having liquid nitrogen dioxide and capable of diffusing gaseous nitrogen dioxide into an air flow; and a receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the air flow from the permeation cell and fluidly communicate the air flow to the outlet through the surface-active material such that the surface-active material reacts with the gaseous nitrogen dioxide to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification