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Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents

  • US 7,560,431 B2
  • Filed: 08/12/2005
  • Issued: 07/14/2009
  • Est. Priority Date: 06/20/2003
  • Status: Expired due to Fees
First Claim
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1. A method of delivering a therapeutic or diagnostic/investigational agent across the blood brain baffler (BBB) into the central nervous system in a subject in need thereof, said method comprising:

  • administering to said subject a chimeric RAP fusion protein comprising said therapeutic or diagnostic/investigational agent, wherein the RAP portion of the chimeric RAP fusion protein consists of an amino acid sequence at least 80% identical to amino acids 221-323 of SEQ ID NO;

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