Poly(ethylene glycol) containing chemically disparate endgroups

• US 7,560,588 B2
• Filed: 04/27/2007
• Issued: 07/14/2009
• Est. Priority Date: 04/27/2006
• Status: Expired due to Fees

• Current Assignee: Intezyne Technologies
• Original Assignee: Intezyne Technologies
• Inventors: Skaff, Habib, Breitenkamp, Kurt, Sill, Kevin N.
• Primary Examiner(s): SHIAO, REI TSANG
• Application Number:
  US11/796,385
• Publication Number:
  US 20080207913A1
• Time in Patent Office: 809 Days
• Field of Search: 560/160
• US Class Current: 560/160
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: C07C 217/08 the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 217/84 the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
• CPC Class Codes: C07C 247/04 being saturated
• CPC Class Codes: C07C 271/16 to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
• CPC Class Codes: C07D 207/452 with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 207/46 with hetero atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 213/71 to which a second hetero atom is attached
• CPC Class Codes: C07D 263/14 with radicals substituted by oxygen atoms
• CPC Class Codes: C07D 311/88 Nitrogen atoms
• CPC Class Codes: C07D 317/22 etherified
• CPC Class Codes: C07D 491/08 Bridged systems
• CPC Class Codes: C07D 495/04 Ortho-condensed systems
• CPC Class Codes: C07F 9/3808 Acyclic saturated acids which can have further substituents on alkyl
• CPC Class Codes: C07F 9/4006 Esters of acyclic acids which can have further substituents on alkyl
• CPC Class Codes: C07F 9/42 Halides thereof
• CPC Class Codes: C07F 9/65502 the oxygen atom being part of a three-membered ring
• CPC Class Codes: C07F 9/65505 Phosphonic acids containing oxirane groups; esters thereof
• CPC Class Codes: C07F 9/6552 the oxygen atom being part of a six-membered ring
• CPC Class Codes: C08G 2650/48 containing fluorine, e.g. perfluropolyethers
• CPC Class Codes: C08G 65/2612 : containing aromatic or arylaliphatic hydroxyl groups
• CPC Class Codes: C08G 65/2627 : containing aromatic or arylaliphatic amine groups
• CPC Class Codes: C08G 65/263 : containing heterocyclic amine groups
• CPC Class Codes: C08G 65/325 : containing nitrogen
• CPC Class Codes: C08G 65/329 : with organic compounds
• CPC Class Codes: C08G 65/3322 : acyclic
• CPC Class Codes: C08G 65/33303 : containing amino group
• CPC Class Codes: C08G 65/33337 : cyclic
• CPC Class Codes: C08G 65/33396 : having oxygen in addition to nitrogen
• CPC Class Codes: C08G 65/3353 : containing oxygen in addition to phosphorus
• CPC Class Codes: C08G 65/336 : containing silicon
• CPC Class Codes: C08G 65/337 : containing other elements organic compounds containing halogens only as halides of a carboxyl group C08G65/332
• CPC Class Codes: C08G 65/4006 : (I) or (II) containing elements other than carbon, oxygen, hydrogen or halogen as leaving group (X)
• CPC Class Codes: C08L 2203/02 : for biomedical use

Abstract

The present invention provides bifunctional polymers, methods of preparing the same, and intermediates thereto. These compounds are useful in a variety of applications including the PEGylation of biologically active molecules. The invention also provides methods of using said compounds and compositions thereof.

Claims

1. A compound selected from any of the following formulae:

2. The compound of claim 1, wherein each n is independently about 10 to about 40.

3. The compound of claim 1, wherein each n is independently about 40 to about 60.

4. The compound of claim 1, wherein each n is independently about 60 to about 90.

5. The compound of claim 1, wherein each n is independently about 90 to about 150.

6. The compound of claim 1, wherein each n is independently about 150 to about 200.

7. The compound of claim 1, wherein each n is independently about 200 to about 250.

8. The compound of claim 1, wherein each n is independently about 300 to about 375.

9. The compound of claim 1, wherein each n is independently about 400 to about 500.

10. The compound of claim 1, wherein each n is independently about 650 to about 750.

11. The compound of claim 1, wherein each n is independently 50±

10.

12. The compound of claim 1, wherein each n is independently 80±

10.

13. The compound of claim 1, wherein each n is independently 115±

10.

14. The compound of claim 1, wherein each n is independently 180±

10.

15. The compound of claim 1, wherein each n is independently 225±

10.

16. The compound of claim 1, wherein each n is independently 225.

17. The compound of claim 1, wherein each n is independently 270.

18. The compound of claim 1, wherein said compound is

19. The compound of claim 1, wherein said compound is

20. The compound of claim 1, wherein said compound is

21. The compound of claim 1, wherein said compound is

22. The compound of claim 1, wherein said compound is