Implantable drug delivery device and use thereof
First Claim
Patent Images
1. An implantable drug delivery device, comprising:
- (a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough, wherein the inner volume is in fluid flow communication with the outside of the casing;
(b) a reservoir member comprising a drum disposed within the casing, wherein the reservoir member defines a cavity for receiving the drug; and
(c) a seal attached to the reservoir member for sealing drug within the cavity, which when punctured permits drug disposed within the cavity to be released into the inner volume and to exit the casing via the aperture port defined in the eye-contacting surface.
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Abstract
The invention provides a miniaturized, implantable drug delivery device and a method of delivering over a prolonged period of time one or more drugs using such a device. The drug delivery device can be adapted for attachment to the outer surface of an eye. Once attached to the outer surface of an eye, the device can deliver one or more drugs directly into the eye for preventing or ameliorating the symptoms of a particular ocular disorder.
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Citations
63 Claims
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1. An implantable drug delivery device, comprising:
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(a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough, wherein the inner volume is in fluid flow communication with the outside of the casing; (b) a reservoir member comprising a drum disposed within the casing, wherein the reservoir member defines a cavity for receiving the drug; and (c) a seal attached to the reservoir member for sealing drug within the cavity, which when punctured permits drug disposed within the cavity to be released into the inner volume and to exit the casing via the aperture port defined in the eye-contacting surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 22, 23, 24, 42, 43, 44, 45)
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12. An implantable drug delivery device, comprising:
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(a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough, wherein the inner volume is in fluid flow communication with the outside of the casing; (b) a rotatable drum disposed within the casing and having a surface defining a cavity for receiving the drug; (c) a seal attached to the surface for sealing drug within the cavity; and (d) a puncturing member for breaking the seal to permit drug disposed within the cavity to be released into the inner volume and exit the casing via the aperture port defined in the eve-contacting surface. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 25)
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26. An implantable drug delivery device, comprising:
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(a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough; (b) a rotatable drum disposed within the casing and having a surface defining a plurality of cavities for receiving the drug radially disposed about the drum, wherein all the cavities do not lie in a single diametral plane; and (c) a seal attached to the drum for sealing drug within at least one cavity, which when punctured permits drug disposed within a cavity to exit the casing via the aperture port defined in the eye-contacting surface. - View Dependent Claims (27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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46. An implantable drug delivery device, comprising:
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(a) a casing defining an inner volume, and comprising an outer surface, the outer surface comprising an eye-contacting surface, wherein the eye-contacting surface comprises a shape complementary to an outer surface of a mammalian eye, and wherein when implanted, the eye-contacting surface substantially conforms to the outer surface of a mammalian eye, the eye-contacting surface defining an aperture port passing therethrough; (b) a reservoir member disposed within the casing, wherein the reservoir member defines a plurality of cavities for receiving the drug; and (c) a seal attached to the reservoir member for sealing the cavity, which when punctured permits drug disposed within the cavity to exit the casing through the aperture port defined in the eye-contacting surface. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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Specification