Glucagon-like-peptide-2 (GLP-2) analogues
First Claim
1. A glucagon-like peptide-2 (GLP-2) analog wherein said analog has the amino acid sequence:
- H-HGEGSFSSELSTILDALAARDFIAWLIATKITDK6-NH2 (SEQ ID NO;
34),or a pharmaceutically acceptable salt thereof.
4 Assignments
0 Petitions
Accused Products
Abstract
GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g. as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and/or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and/or a deletion of one or more of amino acids 31 to 33 and/or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy.
-
Citations
2 Claims
-
1. A glucagon-like peptide-2 (GLP-2) analog wherein said analog has the amino acid sequence:
-
H-HGEGSFSSELSTILDALAARDFIAWLIATKITDK6-NH2 (SEQ ID NO;
34),or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2)
-
Specification