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Dynamic imaging of biological cells and other subjects

  • US 7,564,546 B2
  • Filed: 06/30/2005
  • Issued: 07/21/2009
  • Est. Priority Date: 06/30/2004
  • Status: Active Grant
First Claim
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1. A method of cellular imaging to assess an effect of a drug on a cell, the method comprising:

  • (a) illuminating at least a portion of a cell with substantially monochromatic photons;

    (b) detecting Raman-shifted photons scattered from the illuminated portion to thereby form an image corresponding to Raman-shifted photons collected substantially simultaneously from a plurality of different spatial locations of the cell;

    (c) at each of the plurality of different spatial locations of the cell represented by the image, assessing the Raman-shifted photons at a plurality of Raman shift (RS) values characteristic of a pre-selected drug to thereby determine a first state of the cell;

    (d) after a time period following a first iteration of steps (a)-(c), repeating steps (a)-(c) to thereby determine a second state of the cell; and

    (e) comparing the first and second state of the cell to thereby assess an effect of the drug on the cell over the time period.

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