Systems and methods for a high capture angle, multiple angle light scattering (MALS) instrument
First Claim
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1. A system for detecting and identifying a particle in a liquid, the system comprising:
- an optical axis;
a flow cell comprising a target zone, the optical axis intersecting the target zone, the flow cell configured to allow for simultaneous detection of a plurality of analytes;
a reflective optic comprising a first curved reflecting surface and a second surface opposing the first curved surface, the reflective optic coupled with a liquid medium in the target zone, the reflective optic configured to collect and reflect light scatter by the particle in the liquid medium in the target zone;
a detector configured to detect the reflected light; and
a light source configured to generate a light beam and direct the light beam through the target zone at an angle which is not coaxial with the flow cell,wherein the second surface of the reflective optic is parallel along an entire length of the flow cell.
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Abstract
A particle detection system uses a reflective optic comprising a curved surface to detect high angle scattered light generated by a particle in a liquid medium, when a laser beam is incident on the particle. When the particles transit the laser beam, light is scattered in all directions and is described by MIE scattering theory for particles about the size of the wavelength of light and larger or Rayleigh Scattering when the particles are smaller than the wavelength of light. By using the reflective optic, the scattered light can be detected over angles that are greater than normally obtainable.
42 Citations
26 Claims
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1. A system for detecting and identifying a particle in a liquid, the system comprising:
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an optical axis; a flow cell comprising a target zone, the optical axis intersecting the target zone, the flow cell configured to allow for simultaneous detection of a plurality of analytes; a reflective optic comprising a first curved reflecting surface and a second surface opposing the first curved surface, the reflective optic coupled with a liquid medium in the target zone, the reflective optic configured to collect and reflect light scatter by the particle in the liquid medium in the target zone; a detector configured to detect the reflected light; and a light source configured to generate a light beam and direct the light beam through the target zone at an angle which is not coaxial with the flow cell, wherein the second surface of the reflective optic is parallel along an entire length of the flow cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for detecting and identifying a particle in a liquid, the system comprising:
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an optical axis; a flow cell comprising a target zone, the optical axis intersecting the target zone, the flow cell configured to allow for simultaneous detection of a plurality of analytes; an interface optic; a reflective optic comprising a first curved reflecting surface and a second surface opposing the first curved reflecting surface, the reflective optic coupled with a liquid medium in the target zone, the reflective optic configured to collect and reflect light scatter by the particle in the liquid medium in the target zone; a detector configured to detect the reflected light; and a light source configured to generate a light beam and direct the light beam through the target zone at an angle which is not coaxial with the flow cell, wherein the second surface of the reflective optic and the interface optic are parallel along an entire length of the flow cell. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification