Treating a tumor or the like with electric fields at different orientations

• US 7,565,206 B2
• Filed: 12/27/2005
• Issued: 07/21/2009
• Est. Priority Date: 02/17/2000
• Status: Expired due to Term

• Current Assignee: Novocure GmbH (NovoCure Limited)
• Original Assignee: Standen'S Limited (Standen's Management, Inc.)
• Inventors: Palti, Yoram
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US11/318,702
• Publication Number:
  US 20060167499A1
• Time in Patent Office: 1,302 Days
• Field of Search: 607/76, 607/2, 607/154, 604/20, 604/114, 128/898
• US Class Current: 607/76
• CPC Class Codes: A61N 1/326 for promoting growth of cells, e.g. bone cells
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

Cells that are in the late anaphase or telophase stages of cell division are vulnerable to damage by AC electric fields that have specific frequency and field strength characteristics. The selective destruction of rapidly dividing cells can therefore be accomplished by imposing an AC electric field in a target region for extended periods of time. Some of the cells that divide while the field is applied will be damaged, but the cells that do not divide will not be harmed. This selectively damages rapidly dividing cells like tumor cells, but does not harm normal cells that are not dividing. Since the vulnerability of the dividing cells is strongly related to the alignment between the long axis of the dividing cells and the lines of force of the electric field, improved results are obtained when the field is sequentially imposed in different directions. The field may also be rotated through 360° by applying AC waveforms with different phases to the electrodes.

Claims

1. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

imposing an AC electric field in the target region of the patient with a field orientation that rotates with respect to the target region, wherein the electric field has frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the electric field is strong enough to damage, during the late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with the lines of force of the electric field, and wherein the electric field leaves non-dividing cells located within the target region substantially unchanged; and

repeating the imposing step until a therapeutically significant portion of the rapidly dividing cells die.

2. The method of claim 1, wherein the electric field is imposed in the target region via insulated electrodes.

3. The method of claim 1, wherein the frequency of the electric field is between about 50 kHz and about 500 kHz and the strength of the electric field in at least a portion of the target region is at least 0.1 V/cm.

4. The method of claim 1, wherein the frequency of the electric field is between about 100 kHz and about 300 kHz and the strength of the electric field in at least a portion of the target region is between about 1 V/cm and about 10 V/cm.

5. The method of claim 4, wherein the orientation of the electric field rotates at about 4 rotations per second.

6. The method of claim 1, wherein the orientation of the electric field rotates at about 4 rotations per second.

7. The method of claim 1, wherein the orientation of the electric field rotates at a rate that is the reciprocal of the frequency of the electric field.

8. The method of claim 1, wherein the rotation of the AC electric field is accomplished by simultaneously applying non-identical AC voltages to at least 3 electrodes.

9. The method of claim 1, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals at a first frequency to each of at least 3 electrodes, wherein the signal applied to each of the electrodes is modulated by a sinusoidal signal at a second frequency that is at least ten times lower than the first frequency, and the modulating sinusoidal signals are phase shifted with respect to each other.

10. A method of selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, comprising the steps of:

imposing an AC electric field in the target region of the patient with a field orientation that rotates with respect to the target region, wherein the electric field has frequency and field strength characteristics that cause the electric field to selectively damage cells that are undergoing cell division, and wherein the electric field leaves cells that are not undergoing cell division substantially unharmed; and

repeating the imposing step until a therapeutically significant portion of the rapidly dividing cells die.

11. The method of claim 10, wherein the electric field is imposed in the target region via insulated electrodes.

12. The method of claim 10, wherein the frequency of the electric field is between about 50 kHz and about 500 kHz and the strength of the electric field in at least a portion of the target region is at least 0.1 V/cm.

13. The method of claim 10, wherein the frequency of the electric field is between about 100 kHz and about 300 kHz and the strength of the electric field in at least a portion of the target region is between about 1 V/cm and about 10 V/cm.

14. The method of claim 13, wherein the orientation of the electric field rotates at about 4 rotations per second.

15. The method of claim 10, wherein the orientation of the electric field rotates at about 4 rotations per second.

16. The method of claim 10, wherein the orientation of the electric field rotates at a rate that is the reciprocal of the frequency of the electric field.

17. The method of claim 10, wherein the rotation of the AC electric field is accomplished by simultaneously applying non-identical AC voltages to at least 3 electrodes.

18. The method of claim 10, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals at a first frequency to each of at least 3 electrodes, wherein the signal applied to each of the electrodes is modulated by a sinusoidal signal at a second frequency that is at least ten times lower than the first frequency, and the modulating sinusoidal signals are phase shifted with respect to each other.

19. An apparatus for selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, the apparatus comprising:

at least three insulated electrodes, wherein each of the electrodes has a surface configured for placing against the patient'"'"'s body; and

an AC voltage source having at least three outputs, each output being electrically connected to a respective one of the electrodes,

wherein the AC voltage source and the electrodes are configured so that when the electrodes are placed against the patient'"'"'s body, an AC electric field is imposed in the target region of the patient with an orientation that rotates with respect to the target region, the imposed electric field having frequency characteristics that correspond to a vulnerability of the rapidly dividing cells, wherein the electric field is strong enough to damage, during the late anaphase or telophase stages of cell division, a significant portion of the rapidly dividing cells whose long axis is generally aligned with the lines of force of the electric field, and wherein the electric field leaves non-dividing cells located within the target region substantially unchanged.

20. The apparatus of claim 19, wherein the surface of each of the electrodes is insulated from the AC voltage source by a thin dielectric coating that has a very high dielectric constant.

21. The apparatus of claim 19, wherein the frequency of the electric field is between about 50 kHz and about 500 kHz and the strength of the electric field in at least a portion of the target region is at least 0.1 V/cm.

22. The apparatus of claim 19, wherein the frequency of the electric field is between about 100 kHz and about 300 kHz and the strength of the electric field in at least a portion of the target region is between about 1 V/cm and about 10 V/cm.

23. The apparatus of claim 22, wherein the orientation of the electric field rotates at about 4 rotations per second.

24. The apparatus of claim 19, wherein the orientation of the electric field rotates at about 4 rotations per second.

25. The apparatus of claim 19, wherein the orientation of the electric field rotates at a rate that is the reciprocal of the frequency of the electric field.

26. The apparatus of claim 19, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals to each of the electrodes, wherein the sinusoidal signals are phase shifted with respect to each other.

27. The apparatus of claim 19, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals at a first frequency to each of the electrodes, wherein the signal applied to each electrode is modulated by a sinusoidal signal at a second frequency that is at least ten times lower than the first frequency, and the modulating sinusoidal signals are phase shifted with respect to each other.

28. An apparatus for selectively destroying or inhibiting the growth of rapidly dividing cells located within a target region of a patient, the apparatus comprising:

at least three insulated electrodes, wherein each of the electrodes has a surface configured for placing against the patient'"'"'s body; and

an AC voltage source having at least three outputs, each output being electrically connected to a respective one of the electrodes,

wherein the AC voltage source and the electrodes are configured so that, when the electrodes are placed against the patient'"'"'s body, an AC electric field is imposed in the target region of the patient with an orientation that rotates with respect to the target region, the imposed electric field having frequency and field strength characteristics that cause the electric field to (a) selectively damage cells that are undergoing cell division and (b) leave cells that are not undergoing cell division substantially unharmed.

29. The apparatus of claim 28, wherein the surface of each of the electrodes is insulated from the AC voltage source by a thin dielectric coating that has a very high dielectric constant.

30. The apparatus of claim 28, wherein the frequency of the electric field is between about 50 kHz and about 500 kHz and the strength of the electric field in at least a portion of the target region is at least 0.1 V/cm.

31. The apparatus of claim 28, wherein the frequency of the electric field is between about 100 kHz and about 300 kHz and the strength of the electric field in at least a portion of the target region is between about 1 V/cm and about 10 V/cm.

32. The apparatus of claim 31, wherein the orientation of the electric field rotates at about 4 rotations per second.

33. The apparatus of claim 28, wherein the orientation of the electric field rotates at about 4 rotations per second.

34. The apparatus of claim 28, wherein the orientation of the electric field rotates at a rate that is the reciprocal of the frequency of the electric field.

35. The apparatus of claim 28, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals to each of the electrodes, wherein the sinusoidal signals are phase shifted with respect to each other.

36. The apparatus of claim 28, wherein the rotation of the AC electric field is accomplished by simultaneously applying sinusoidal signals at a first frequency to each of the electrodes, wherein the signal applied to each electrode is modulated by a sinusoidal signal at a second frequency that is at least ten times lower than the first frequency, and the modulating sinusoidal signals are phase shifted with respect to each other.