Biochemical concentrator and drug discovery
First Claim
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1. A biochemical concentrator apparatus comprising:
- a solution containing a target species,one or more electric field generators for generating electric fields and for effecting movement of the target species within the solution and changing species flux within regions of the solution,a sensor having receptors for the target species,one or more voltage sources connected to the one or more electric field generators, andfurther comprising a ground connected to the sensor and to the one or more sources,wherein the one or more electric field generators can concentrate the target species in the region of the solution nearest the sensor and remove the target species from that region and from the vicinity of the one or more electric field generators, without necessarily applying an electric field in the area around the sensor during operation,wherein the one or more electric field generators comprise one or more electrodes spaced from the sensor,wherein the one or more electrodes comprise one or more grids surrounding the sensor and spaced between the sensor and each respective electrode'"'"'s voltage source.
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Abstract
A novel label-free sensitive detection method by employing a novel sensitive charge sensor is provided. Dissociation constant information is provided by a simple measurement of the dissociation of the target molecule form the target'"'"'s receptor. The later process is affected by a novel system and its configuration as described herein. Basic objectives are to provide a drug discovery and characterization system that is an improvement over the current state of the art, low cost, highly sensitive, accurate, fast and easy to use. This invention involves both a physical system and a methodology.
17 Citations
4 Claims
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1. A biochemical concentrator apparatus comprising:
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a solution containing a target species, one or more electric field generators for generating electric fields and for effecting movement of the target species within the solution and changing species flux within regions of the solution, a sensor having receptors for the target species, one or more voltage sources connected to the one or more electric field generators, and further comprising a ground connected to the sensor and to the one or more sources, wherein the one or more electric field generators can concentrate the target species in the region of the solution nearest the sensor and remove the target species from that region and from the vicinity of the one or more electric field generators, without necessarily applying an electric field in the area around the sensor during operation, wherein the one or more electric field generators comprise one or more electrodes spaced from the sensor, wherein the one or more electrodes comprise one or more grids surrounding the sensor and spaced between the sensor and each respective electrode'"'"'s voltage source.
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2. The apparatus of claim 1, further comprising multiple grids surrounding the sensor and multiple voltage sources connected between the grids.
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3. The apparatus of claim 2, wherein the multiple grids are shaped for effecting concentrations of the species near the sensor.
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4. The apparatus of claim 2, wherein the source provides pulsed, alternating, sinusoidal or other DC or AC power to the field generator.
Specification
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Current AssigneeUniversity of Hawai'i
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Original AssigneeUniversity of Hawai'i
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InventorsHolm-Kennedy, James W.
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Primary Examiner(s)Nguyen; Bao-Thuy L
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Assistant Examiner(s)DIRAMIO, JACQUELINE A
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Application NumberUS11/083,107Publication NumberTime in Patent Office1,593 DaysField of Search204/403.01, 204/403.03, 204/193, 204/400, 422/50, 422/68.1, 429/92, 436/501, 435/4, 435/7.1, 435/287.1, 435/287.2US Class Current422/68.1CPC Class CodesG01N 27/3276 being a hybridisation with ...
