Self-calibrating rate-adaptive pacemaker

• US 7,567,839 B2
• Filed: 07/13/2006
• Issued: 07/28/2009
• Est. Priority Date: 09/08/2000
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Lang, Douglas J., Hopper, Donald, Sun, Weimin, Jones, Bruce R.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US11/457,382
• Publication Number:
  US 20060247704A1
• Time in Patent Office: 1,111 Days
• Field of Search: 607 17- 20, 607/9, 607/27
• US Class Current: 607/19
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

Claims

1. A system for automatically adjusting responsiveness of a rate-adaptive pacemaker by using a rate response curve mapping measured exertion levels to a sensor indicated rate, the system comprising:

means for collecting short-term maximum exertion levels and short-term maximum sensor indicated rates;

means for computing an intermediate-term average maximum exertion level being an average of the short-term maximum exertion levels and an intermediate-term average maximum sensor indicated rate being an average of the short-term maximum sensor indicated rates;

means for computing a sensor target rate as a function of the intermediate-term average maximum exertion level and a long-term maximum exertion level; and

means for periodically adjusting a slope of the rate response curve using the intermediate-term average maximum sensor indicated rate and the sensor target rate.

2. The system of claim 1, further comprising:

means for periodically updating the long-term maximal exertion level using the short-term maximum exertion levels collected during a specified time period; and

means for adjusting the slope of the rate response curve for the updated long-term maximal exertion level to be mapped to a specified maximum sensor indicated rate.

3. The system of claim 2, further comprising means for adjusting the slope of the rate response curve by a specified step amount so as to increase or decrease the responsiveness of the pacemaker in accordance with whether the intermediate-term average maximum sensor indicated rate is lesser or greater than the sensor target rate.

4. The system of claim 2, further comprising means for sensing a signal that is an approximation to oxygen consumption, and the short-term maximum exertion levels are collected using the sensed signal.

5. A system for automatically adjusting a rate-adaptive pacemaker, the system comprising:

a sensor adapted to sense exertion levels; and

a microprocessor coupled to the sensor, the microprocessor adapted to;

collect short-term maximum exertion levels using the exertion levels sensed during a specified short-term period;

compute an intermediate-term average maximum exertion level being an average of the short-term maximum exertion levels collected during a specified intermediate-term period;

adjust a slope of a rate response curve using the intermediate-term average maximum exertion level and a long-term maximum exertion level, the rate response curve mapping the exertion levels to a pacing rate; and

adjust the pacing rate using the sensed exertion levels and the rate response curve.

6. The system of claim 5, wherein the sensor is adapted to sense a signal being an approximation to oxygen consumption.

7. The system of claim 6, wherein the sensor comprises a minute ventilation sensor.

8. The system of claim 5, wherein the sensor comprises an accelerometer.

9. The system of claim 5, wherein the microprocessor is adapted to adjust the slope of the rate response curve periodically.

10. The system of claim 9, wherein the microprocessor is adapted to update the long-term maximal exertion level periodically using the short-term maximum exertion levels collected during a specified time period.

11. The system of claim 10, wherein the microprocessor is adapted to:

collect short-term maximum sensor indicated rates by using the short-term maximum exertion levels and the rate response curve;

compute an intermediate-term average maximum sensor indicated rate being an average of the short-term maximum sensor indicated rates collected during the specified intermediate-term period;

compute a sensor target rate as a function of the intermediate-term average maximum exertion level and the long-term maximum exertion level; and

adjust the slope of the rate response curve using the intermediate-term average maximum sensor indicated rate and the sensor target rate.

12. A method for adjusting a rate-adaptive pacemaker, the method comprising:

sensing exertion levels;

adjusting a pacing rate using the sensed exertion levels and a rate response curve mapping the exertion levels to the pacing rate;

collecting short-term maximum exertion levels using the exertion levels sensed during a specified short-term period;

computing an intermediate-term average maximum exertion level being an average of the short-term maximum exertion levels collected during a specified intermediate-term period; and

adjusting a slope of the rate response curve using the intermediate-term average maximum exertion level and a long-term maximum exertion level.

13. The method of claim 12, wherein sensing the exertion levels comprises sensing a signal that is an approximation to oxygen consumption.

14. The method of claim 13, wherein sensing the exertion levels comprises sensing a minute ventilation being a function of ventilation rate and tidal volume.

15. The method of claim 12, wherein sensing the exertion levels comprises sensing body activity.

16. The method of claim 12, further comprising updating the long-term maximum exertion level periodically using the short-term maximum exertion levels.

17. The method of claim 16, wherein adjusting the slope of the rate response curve comprises:

collecting short-term maximum sensor indicated rates by using the short-term maximum exertion levels and the rate response curve;

computing an intermediate-term average maximum sensor indicated rate being an average of the short-term maximum sensor indicated rates collected during the specified intermediate-term period;

computing a sensor target rate as a function of the intermediate-term average maximum exertion level and the long-term maximum exertion level; and

adjusting the slope of the rate response curve using the intermediate-term average maximum sensor indicated rate and the sensor target rate.

18. The method of claim 16, wherein adjusting the pacing rate comprises adjusting a lower rate limit.

19. The method of claim 16, wherein collecting the short-term maximum exertion levels comprises:

computing moving average values of the sensed exertion levels during the specified short-term period; and

storing a maximum value of the moving average values of the sensed exertion levels.

20. The method of claim 19, wherein collecting the short-term maximum sensor indicated rates comprises:

computing maximum moving average values of the sensor indicated rates during the specified short-term period; and

storing a maximum value of the moving average values of the sensor indicated rates.