Method and apparatus for delivering combined electrical and drug therapies
First Claim
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1. A cardiac rhythm management (CRM) system, comprising:
- an implantable medical device including;
a pulse output circuit to deliver electrical pulses;
a drug delivery device adapted to start releasing a drug in response to a drug delivery signal, the drug delivery device including;
a drug reservoir containing a drug for treating heart failure; and
a reservoir filling port connected to the drug reservoir;
a sensor circuit to sense one or more signals indicative of a need for and an effect of the delivery of the electrical pulses and the drug;
an implant controller, coupled to the pulse output circuit, the drug delivery device, and the sensor circuit, the implant controller including a sensor processing circuit adapted to process the one or more signals and a therapy controller adapted to control delivery of the electrical pulses and the drug using the processed one or more signals, the therapy controller adapted to produce the drug delivery signal in response to at least an external command and execute a pacing algorithm adapted to enhance one or more effects of the drug, the therapy controller adapted to control delivery of pacing pulses by alternately executing a cardiac resynchronization therapy (CRT) algorithm adapted to maximize a measure of hemodynamic performance and a remodeling control therapy (RCT) algorithm adapted to alter a cardiac remodeling process; and
an implantable housing to contain the pulse output circuit, the drug delivery device, and the implant controller,wherein the reservoir filling port is constructed on the implantable housing and includes a self-resealable portion adapted to allow filling of the drug reservoir using a hollow needle; and
an external system including an external device, a network, and a remote device, the external device communicatively coupled to the implantable medical device via telemetry, the network providing for communication between the external device and the remote device, the remote device including a user input device adapted to receive the external command.
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Abstract
A cardiac rhythm management (CRM) system includes an implantable medical device that delivers combined electrical and drug therapies. The implantable medical device includes a drug reservoir that is refillable after implantation. In one embodiment, the implantable medical device includes an implantable housing encapsulating a pulse generator circuit and a drug delivery device. In another embodiment, the implantable medical device includes an implantable pulse generator and an implantable drug delivery device fastened to each other.
202 Citations
17 Claims
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1. A cardiac rhythm management (CRM) system, comprising:
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an implantable medical device including; a pulse output circuit to deliver electrical pulses; a drug delivery device adapted to start releasing a drug in response to a drug delivery signal, the drug delivery device including; a drug reservoir containing a drug for treating heart failure; and a reservoir filling port connected to the drug reservoir; a sensor circuit to sense one or more signals indicative of a need for and an effect of the delivery of the electrical pulses and the drug; an implant controller, coupled to the pulse output circuit, the drug delivery device, and the sensor circuit, the implant controller including a sensor processing circuit adapted to process the one or more signals and a therapy controller adapted to control delivery of the electrical pulses and the drug using the processed one or more signals, the therapy controller adapted to produce the drug delivery signal in response to at least an external command and execute a pacing algorithm adapted to enhance one or more effects of the drug, the therapy controller adapted to control delivery of pacing pulses by alternately executing a cardiac resynchronization therapy (CRT) algorithm adapted to maximize a measure of hemodynamic performance and a remodeling control therapy (RCT) algorithm adapted to alter a cardiac remodeling process; and an implantable housing to contain the pulse output circuit, the drug delivery device, and the implant controller, wherein the reservoir filling port is constructed on the implantable housing and includes a self-resealable portion adapted to allow filling of the drug reservoir using a hollow needle; and an external system including an external device, a network, and a remote device, the external device communicatively coupled to the implantable medical device via telemetry, the network providing for communication between the external device and the remote device, the remote device including a user input device adapted to receive the external command. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification