Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same

• US 7,569,655 B2
• Filed: 03/21/2007
• Issued: 08/04/2009
• Est. Priority Date: 11/24/2004
• Status: Active Grant

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Tang, Yiwen, Pacetti, Stephen D.
• Primary Examiner(s): Boykin; Terressa M
• Application Number:
  US11/726,661
• Publication Number:
  US 20070167602A1
• Time in Patent Office: 867 Days
• Field of Search: 424/422, 424/423, 424/426, 514/2, 514/6, 514/28, 514/35, 528/190, 528/480, 623/23, 623/57
• US Class Current: 528/190
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08G 2230/00 Compositions for preparing biodegradable polymers
• CPC Class Codes: C08G 63/181 Acids containing aromatic rings
• CPC Class Codes: C08L 67/02 Polyesters derived from dicarboxylic acids and dihydroxy compounds C08L67/06 takes precedence

Abstract

Polymers containing polyesters and, optionally, agents for use with medical articles and methods of fabricating the same are disclosed. The medical article generally comprises an implantable substrate having a coating, and the coating contains a polymer comprising a polymeric product of a reaction comprising a polyol and a polycarboxylic acid.

Claims

1. A polymer comprising a structure of a formula:

2. The polymer of claim 1, wherein X comprises a component selected from a group consisting of poly(ethylene glycol), poly(propylene glycol), poly(N-vinyl pyrrolidone), phosphorylcholine, a glycosaminoglycan, carboxymethylcellulose, hyaluronic acid, heparin, hirudin, poly(acrylamide methyl propane sulfonic acid), poly(styrene sulfonate), sulfonated dextran, dermatan sulfate, RGD, collagen, chitin, chitosan, elastin and any derivatives, analogs, homologues, congeners, salts, copolymers and combinations thereof.

3. The polymer of claim 1, wherein X comprises poly(ethylene glycol), poly(N-vinyl pyrrolidone), phosphorylcholine, hyaluronic acid, heparin, hirudin, or any derivatives, analogs, homologues, congeners, salts, copolymers or combinations thereof.

4. The polymer of claim 1, wherein X comprises a component selected from a group consisting of a free radical scavenger, a nitric oxide donor, rapamycin, everolimus, tacrolimus, paclitaxel, docetaxel, estradiol, clobetasol, idoxifen, tazarotene and any prodrugs, metabolites, analogs, homologues, congeners, and any derivatives, salts and combinations thereof.

5. The polymer of claim 4, wherein the free radical scavenger comprises a component selected from a group consisting of 2,2′

,6,6′

-tetramethyl-1-piperidinyloxy free radical;

4-amino-2,2′

,6,6′

-tetramethyl-1-piperidinyloxy free radical;

4-hydroxy-2,2′

,6,6′

-tetramethyl-piperidene-1-oxy free radical;

2,2′

,3,4,5,5′

-hexamethyl-3-imidazolinium-1-yloxy methyl sulfate free radical;

16-doxyl-stearic acid free radical;

superoxide dismutase mimic; and

any analogs, homologues, congeners, derivatives, salts and combinations thereof.

6. The polymer of claim 4, wherein the free radical scavenger comprises TEMPO or any analogs, homologues, congeners, derivatives, salts or combinations thereof.

7. The polymer of claim 4, wherein the nitric oxide donor comprises a component selected from the group consisting of S-nitrosothiols, nitrites, N-oxo-N-nitrosamines, substrates of nitric oxide synthase, diazenium diolates and any analogs, homologues, congeners, derivatives, salts and combinations thereof.

8. The polymer of claim 1, wherein L₁ and L₂ each comprises a component independently selected from a group consisting of amides, esters, anhydrides, orthoesters, all-aromatic carbonates, ureas, urethanes, semicarbazones, imines, oximes, ketals, acetals, disulfides, or a combination thereof.