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Electrical field therapy with reduced histopathological change in muscle

  • US 7,570,992 B2
  • Filed: 01/13/2004
  • Issued: 08/04/2009
  • Est. Priority Date: 07/13/1998
  • Status: Expired due to Term
First Claim
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1. A method for delivering a therapeutic agent to a subject, comprising;

  • introducing an effective amount of at least one therapeutic agent into a target muscle tissue site of a subject, wherein the therapeutic agent comprises a polynucleotide that encodes a therapeutic protein or peptide; and

    generating an electric field at the target muscle tissue site by introducing from 1 to about 4 monopolar DC pulses, each pulse having a duration of about 10 ms to about 100 ms, to generate a nominal field strength of about 100 V/cm to about 300 V/cm at the target muscle tissue site.

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