Reconstructing non-cartilage structural defects

• US 7,572,221 B2
• Filed: 03/25/2003
• Issued: 08/11/2009
• Est. Priority Date: 10/31/1997
• Status: Expired due to Fees

• Current Assignee: Anthony J. Atala
• Original Assignee: Children's Medical Center Corporation
• Inventors: Yoo, James J., Atala, Anthony
• Primary Examiner(s): Lacyk; John P
• Application Number:
  US10/396,202
• Publication Number:
  US 20050054893A1
• Time in Patent Office: 2,331 Days
• Field of Search: 600/40, 623/11.11, 623/13.11, 623/13.17, 623/13.18, 623 2364- 2366, 623/23.71, 623/23.72, 623/23.75, 623/23.76, 424422-430
• US Class Current: 600/40
• CPC Class Codes: A61F 2/26 Penis implants
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/3817 Cartilage-forming cells, e.g. pre-chondrocytes
• CPC Class Codes: A61L 27/3852 Cartilage, e.g. meniscus
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A cartilaginous structural member (CSM) for use in penile reconstruction, for the correction of developmental defects, postoperative reconstruction, and for reconstructive preprosthetic surgery. The cartilaginous structural member (CSM) comprise of live cells seeded onto pre-formed shaped structure which may be biodegradable. The live cells may comprise chondrocyte and the cartilaginous structural member (CSM) for use in reconstructive surgery may be constructed of polyglycolic acid. The implant structure is applicable to use for the regeneration and reconstruction or augmentation of semirigid members of the body such as the penis, nose, ear and locations which naturally has cartilage. Further, the cartilaginous structural member (CSM) may be used in plastic surgery such as, for example, breast augmentation or pectoral augmentation. The cartilaginous structural member (CSM) may be a composite cartilaginous structural member (CSM) comprising additional anchoring and strengthening elements for anchoring or changing the structural strength of said composite cartilaginous structural member (CSM).

Claims

1. A method for providing structural support to a patient in an area of a non-cartilage structural defect comprising the steps of:

a) providing a polymeric matrix shaped in the form of a desired support member;

b) depositing dissociated cartilage forming cells on and in said matrix to form a matrix/cell construct; and

c) implanting said matrix/cell construct in said patient at a site of a non-cartilage structural defect in need of structural support, wherein said construct forms a cartilaginous structural member having controlled biomechanical properties providing the required structural support in the area of said non-cartilage structural defect.

2. The method of claim 1 wherein step a) further comprises selecting a polymeric matrix comprising a biocompatible material selected from the group consisting of cellulose ether, cellulose, cellulosic ester, fluorinated polyethylene, poly-4-methylpentene, polyacrylonitrile, polyamide, polyarnideimide, polyacrylate, polybenzoxazole, polycarbonate, polycyanoarylether, polyester, polyestercarbonate, polyether, polyetheretherketone, polyetherimide, polyetherketone, polyethersulfone, polyethylene, polyfluoroolefin, polyimide, polyolefin, polyoxadiazole, polyphenylene oxide, polyphenylene sulfide, polypropylene, polystyrene, polysulfide, polysulfone, polytetrafluoroethylene, polythioether, polytriazole, polyurethane, polyvinyl, polyvinylidene fluoride, regenerated cellulose, silicone, urea-formaldehyde, or copolymers or physical blends thereof, that is in the shape of a desired support member.

3. The method of claim 2 further comprising selecting a polymeric matrix that comprises a biodegradable material.

4. The method of claim 3 further comprising selecting a polymeric matrix that comprises a biodegradable material selected from the group consisting of a polyglycolic acid polymer, a polyglactin polymer, and mixtures and composites thereof.

5. The method of claim 1 wherein step b) comprises depositing chondrocytes on and in said matrix to form a matrix/cell construct.

6. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising an elongated cylinder further comprising a means adapted to receive a urethra.

7. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising an elongated cylinder further comprising a longitudinal groove along its length.

8. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising a hollow cylindrical tube with a wall thickness and a bore along its length.

9. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising a hollow cylindrical tube adapted to receive a urethra with a wall thickness and a bore along its length.

10. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising a hollow cylindrical tube adapted to receive a urethra with a wall thickness that is variable and a bore along its length.

11. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising a cylinder that has a variable structure strength along its longitudinally length.

12. The method of claim 1 wherein step a) comprises providing a polymeric matrix in the shape of a support member comprising a cylinder that comprises an anchoring means on one end for the attachment of said implant to the descending pelvis.

13. A method for providing structural support to a patient in an area of a non-cartilage structural defect comprising the steps of:

a) providing a polymeric matrix shaped in the form of a desired support member;

b) depositing dissociated cartilage forming cells on and in said matrix to form a matrix/cell construct; and

c) implanting said matrix/cell construct in said patient at a site of a non-cartilage structural defect in need of structural support, wherein said construct forms a cartilaginous structural member having a tensile strength of at least about 2.2 kg providing the required structural support in the area of said non-cartilage structural defect.

14. A method for providing structural support to a patient in an area of a non-cartilage structural defect comprising the steps of:

a) providing a polymeric matrix shaped in the form of a desired support member;

b) depositing dissociated cartilage forming cells on and in said matrix to form a matrix/cell construct; and

c) implanting said matrix/cell construct in said patient at a site of a non-cartilage structural defect in need of structural support, wherein said construct forms a cartilaginous structural member having a tensile strength of at least about 3.7 kg providing the required structural support in the area of said non-cartilage structural defect.

15. A method for providing structural support to a patient in an area of a non-cartilage structural defect comprising the steps of:

a) providing a polymeric matrix shaped in the form of a desired support member;

b) depositing dissociated cartilage forming cells on and in said matrix to form a matrix/cell construct; and

c) implanting said matrix/cell construct in said patient at a site of a non-cartilage structural defect in need of structural support, wherein said construct forms a cartilaginous structural member that can withstand cyclic compression performed at rates of from 500 μ

m per second to 20,000 μ

m per second thereby providing the required structural support in the area of said non-cartilage structural defect.