System and method for monitoring autonomic balance and physical activity

• US 7,572,226 B2
• Filed: 10/28/2003
• Issued: 08/11/2009
• Est. Priority Date: 10/28/2003
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Carlson, Gerrard M., Hopper, Donald, Scheiner, Avram
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US10/695,430
• Publication Number:
  US 20050090719A1
• Time in Patent Office: 2,114 Days
• Field of Search: None
• US Class Current: 600/485
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.

Claims

1. An implantable device comprising:

an autonomic tone sensor to provide a tone signal as a function of a sympathetic nervous system and as a function of a parasympathetic nervous system for a predetermined period of time;

an activity sensor to provide an activity signal as a function of physical activity corresponding to the predetermined period; and

an information processing unit connected to the autonomic tone sensor and connected to the activity sensor and adapted to generate an output signal based upon a relationship between the tone signal and the activity signal, establish a baseline that correlates different tone signals with different activity signals over a predetermined period of time, compare the output signal to the baseline, and classify a patient'"'"'s health status based upon the comparison.

2. The device of claim 1 wherein the autonomic tone sensor includes at least one sensor selected from any combination of a group including a heart rate sensor, a nerve electrode, a biochemical sensor, a ventilation sensor and a muscle activity sensor.

3. The device of claim 1 wherein the activity sensor includes an adaptive rate therapy sensor.

4. The device of claim 1 wherein the activity sensor includes at least one sensor selected from any combination of a group including a minute ventilation sensor, an accelerometer, a respiratory sensor, a QT interval sensor, an impedance sensor, a contractility sensor and a depolarization sensor.

5. The device of claim 1 further including a telemetry circuit connected to the information processing unit to communicate with a remote device.

6. The device of claim 1 further including a therapy circuit connected to the information processing unit.

7. The device of claim 6 wherein the therapy circuit includes a pulse generator.

8. The device of claim 1 further including a memory connected to the information processing unit and adapted to store a code as a function of the output signal.

9. The device of claim 1 wherein the autonomic tone sensor includes an implanted electrical lead.

10. The device of claim 1 wherein the information processing unit includes a processor.

11. A method comprising:

generating an autonomic tone signal as a function of autonomic tone detected during an epoch using an implantable sensor;

obtaining an activity signal as a function of physical activity during the epoch; and

generating an output signal based upon a relationship between the tone signal and the activity signal, establishing a baseline that correlates different tone signals with different activity signals over a predetermined period of time, comparing the output signal to the baseline, and classifying a patient'"'"'s health status based upon the comparison.

12. The method of claim 11 wherein generating an autonomic tone signal includes determining heart rate variability.

13. The method of claim 12 wherein determining heart rate variability includes measuring intervals between successive heart beats.

14. The method of claim 11 wherein obtaining the activity signal includes receiving a minute ventilation signal.

15. The method of claim 14 wherein receiving the minute ventilation signal includes determining an impedance.

16. The method of claim 11 wherein obtaining the activity signal includes receiving an acceleration signal.

17. The method of claim 11 further including classifying the autonomic tone signal as a function of the activity signal for the epoch.

18. The method of claim 17 further including comparing the epoch with stored data accessible to an implantable processor.

19. The method of claim 18 wherein the stored data includes data derived from a selected population.

20. The method of claim 11 wherein generating an output signal includes providing a warning.