Cleavable linkers for polynucleotides
First Claim
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1. A method comprising:
- contacting a polynucleotide bound to a substrate via a cleavable linker with a solution comprising an α
-effect nucleophile to result in cleavage of the polynucleotide from the substrate;
wherein the cleavable linker has a structure selected from structures (I), (II), (III), (IV), or (V);
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Abstract
In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.
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Citations
27 Claims
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1. A method comprising:
contacting a polynucleotide bound to a substrate via a cleavable linker with a solution comprising an α
-effect nucleophile to result in cleavage of the polynucleotide from the substrate;
wherein the cleavable linker has a structure selected from structures (I), (II), (III), (IV), or (V);- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- 18. A composition comprising a polynucleotide bound to a substrate via a cleavable linker, wherein the cleavable linker has a structure selected from structures (I), (II), (III), (IV), or (V):
Specification