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Cleavable linkers for polynucleotides

  • US 7,572,908 B2
  • Filed: 03/23/2006
  • Issued: 08/11/2009
  • Est. Priority Date: 03/23/2006
  • Status: Active Grant
First Claim
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1. A method comprising:

  • contacting a polynucleotide bound to a substrate via a cleavable linker with a solution comprising an α

    -effect nucleophile to result in cleavage of the polynucleotide from the substrate;

    wherein the cleavable linker has a structure selected from structures (I), (II), (III), (IV), or (V);

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