Method and apparatus for the administration of CO

• US 7,574,246 B2
• Filed: 06/27/2003
• Issued: 08/11/2009
• Est. Priority Date: 07/04/2002
• Status: Expired due to Term

• Current Assignee: Mallinckrodt Critical Care Finance Inc (Mallinckrodt plc), Mallinckrodt Pharma Ip Trading DAC (Mallinckrodt plc), Therakos, Inc (Mallinckrodt plc)
• Original Assignee: INO Therapeutics GmbH
• Inventors: Krebs, Christian, Mullner, Rainer
• Primary Examiner(s): Nasser; Robert L
• Application Number:
  US10/520,270
• Publication Number:
  US 20060093681A1
• Time in Patent Office: 2,237 Days
• Field of Search: None
• US Class Current: 600/345
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 16/10 Preparation of respiratory gases or vapours
• CPC Class Codes: A61M 16/12 by mixing different gases
• CPC Class Codes: A61M 16/202 electrically actuated
• CPC Class Codes: A61M 2202/0233 Carbon monoxide
• CPC Class Codes: A61M 2202/0291 Xenon
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: A61M 2230/207 hematocrit
• CPC Class Codes: A61M 2230/437 the anaesthetic agent concentration
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

Claims

1. An apparatus for administering carbon monoxide to a patient, the apparatus comprising a delivering unit;

a carbon monoxide source connected to the delivering unit;

a dosing unit connected to the delivering unit and carbon monoxide source, wherein the mass flow between the delivering unit and the carbon monoxide source is controlled by the dosing unit;

at least one sensor unit that determines the concentration of carbon monoxide in the patient'"'"'s blood;

a control unit in communication with the sensor unit and the dosing unit, wherein the control unit regulates the dosing unit depending on feedback from the sensor unit, automatically compares the actual concentration of carbon monoxide in the blood with a preset desired value, and regulates the dosing unit to adjust the amount of carbon monoxide delivered to the patient to obtain a concentration in the blood corresponding to the preset desired value; and

a filter unit though which the air expired by the patient is passed in order to remove excess carbon monoxide from the expired gas, wherein the filter is a physical or a chemical filter.

2. An apparatus for administering carbon monoxide to a patient, the apparatus comprising a delivering unit;

a carbon monoxide source;

a dosing unit for administering carbon monoxide to the patient;

a sensor for determining the concentration of carbon monoxide in the blood; and

a controller for regulating the dosing unit depending on feedback from the sensor unit, wherein the concentration of carbon monoxide in the blood is determined by measuring the concentration of oxyhemoglobin (HbO₂) in the blood.

3. An apparatus for administering carbon monoxide to a patient, the apparatus comprising a delivering unit;

a carbon monoxide source;

a dosing unit for administering carbon monoxide to the patient;

a sensor for determining the concentration of carbon monoxide in the blood; and

a controller for regulating the dosing unit depending on feedback from the sensor unit;

wherein the concentration of carbon monoxide in the blood is determined by measuring the activity of enzymes in the blood.

4. A method for administering carbon monoxide to a patient, comprising:

(a) administering exogenous carbon monoxide to the patient;

(b) determining the concentration of carbon monoxide in the patient'"'"'s blood by measuring the concentration of oxyhemoglobin (HbO₂) in the blood;

(c) comparing the actual concentration of carbon monoxide in the blood with a preset, desired value; and

(d) subsequently adjusting the amount of carbon monoxide delivered to the patient to obtain a concentration in the patient'"'"'s blood corresponding to the preset desired value,

wherein steps (a) through (d) are performed using an apparatus comprising a delivering unit, a carbon monoxide source, a dosing unit for administering carbon monoxide to the patient, a sensor for determining the concentration of carbon monoxide in the blood, and a controller for regulating the dosing unit depending on feedback from the sensor unit.

5. A method for administering carbon monoxide to a patient, comprising:

(a) administering exogenous carbon monoxide to the patient;

(b) determining the concentration of carbon monoxide in the patient'"'"'s blood by measuring the activity of enzymes in the blood;

(c) comparing the actual concentration of carbon monoxide in the blood with a preset, desired value; and

(d) subsequently adjusting the amount of carbon monoxide delivered to the patient to obtain a concentration in the patient'"'"'s blood corresponding to the preset desired value, wherein steps (a) through (d) are performed using an apparatus comprising a delivering unit, a carbon monoxide source, a dosing unit for administering carbon monoxide to the patient, a sensor for determining the concentration of carbon monoxide in the blood, and a controller for regulating the dosing unit depending on feedback from the sensor unit.

6. A method for administering carbon monoxide to a patient, comprising:

(a) administering exogenous carbon monoxide to the patient;

(b) determining the concentration of carbon monoxide in the patient'"'"'s blood;

(c) comparing the actual concentration of carbon monoxide in the blood with a preset, desired value; and

(d) subsequently adjusting the amount of carbon monoxide delivered to the patient to obtain a concentration in the patient'"'"'s blood corresponding to the preset desired value, wherein steps (a) through (d) are performed using an apparatus comprising;

a delivering unit;

a carbon monoxide source;

a dosing unit for administering carbon monoxide to the patient;

a sensor for determining the concentration of carbon monoxide in the blood; and

a controller for regulating the dosing unit depending on feedback from the sensor unit;

wherein the carbon monoxide is delivered for inhalation in pulses, wherein the pulses are inspiration or expiration triggered.

7. A method for administering carbon monoxide to a patient, comprising:

(a) administering exogenous carbon monoxide to the patient;

(b) determining the concentration of carbon monoxide in the patient'"'"'s blood;

(c) comparing the actual concentration of carbon monoxide in the blood with a preset, desired value; and

(d) subsequently adjusting the amount of carbon monoxide delivered to the patient to obtain a concentration in the patient'"'"'s blood corresponding to the preset desired value, wherein steps (a) through (d) are performed using an apparatus comprising;

a delivering unit;

a carbon monoxide source;

a dosing unit for administering carbon monoxide to the patient;

a sensor for determining the concentration of carbon monoxide in the blood; and

a controller for regulating the dosing unit depending on feedback from the sensor unit;

wherein the administration of carbon monoxide is performed via sequences of pulses, wherein the number and length of the pulses in each sequence or the number of sequences, or both, is regulated depending on the determination of the concentration of carbon monoxide in the blood.

8. A method for administering carbon monoxide to a patient, the method comprising:

a) administering exogenous carbon monoxide to the patient by inhalation, wherein the carbon monoxide is delivered for inhalation in pulses triggered by inspiration, expiration or both;

b) determining the concentration of carbon monoxide in the patient'"'"'s blood;

c) comparing the actual concentration of carbon monoxide in the blood with a preset, desired value; and

d) subsequently adjusting the amount of carbon monoxide delivered to the patient to obtain a concentration in the patient'"'"'s blood corresponding to the preset desired value.

9. The method of claim 8, wherein steps (b) through (d) are repeated at least once.

10. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the concentration of carboxyhemoglobin (HbCO) in the blood.

11. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the concentration of oxyhemoglobin (HbO₂) in the blood.

12. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the activity of enzymes in the blood.

13. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the CO content of the air expired by the patient.

14. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the concentration of HbCO in the blood by non-invasive measurement or from a blood sample.

15. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by measuring the concentration of HbO₂ in the blood by oxymetry.

16. The method of claim 8, wherein measuring the carbon monoxide content of the expired air is performed spectroscopically or electrochemically.

17. The method of claim 8, wherein the carbon monoxide is administered to a patient in a gas mixture by admixing it into the breathing air of a patient.

18. The method of claim 8, wherein the concentration of carbon monoxide in the blood is controlled by the oxygen content of the breathing gas.

19. The method of claim 8, wherein the administration of carbon monoxide is performed via sequences of pulses, wherein the number and length of the pulses in each sequence and/or the number of sequences is regulated depending on the determination of the concentration of carbon monoxide in the blood.

20. The method of claim 8, wherein the patient is spontaneously breathing or artificially breathing.

21. The method of claim 8, wherein the concentration of carbon monoxide in the blood is determined by at least two separate methods of measurement.

22. The method of claim 8, wherein the preset value is between about 0.5% to 50% carboxyhemoglobin per total hemoglobin.

23. The method of claim 8, wherein the preset value is between about 5% to 20% carboxyhemoglobin per total hemoglobin.

24. The method of claim 8, wherein the preset value is between about 5% to 15% carboxyhemoglobin per total hemoglobin.

25. The method of claim 8, wherein the preset value is about 8% carboxyhemoglobin per total hemoglobin.