Iontophoretic device and method of delivery of active agents to biological interface
First Claim
1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
- an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising;
a first compartment having a diluent;
a second compartment having an active agent; and
a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding, wherein, when the electrical potential is applied to the active electrode, the polymer complex layer disintegrates to allow the active agent and the diluent to mix.
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Accused Products
Abstract
An iontophoresis device includes: an active electrode element operable to provide an electrical potential; an inner active agent reservoir comprising: a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding. The polymer complex is electrically responsive and disintegrates when an electrical field is applied. The active agent and the diluent become mixed to form a transient solution or dispersion prior to administration of the active agent
180 Citations
24 Claims
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1. An iontophoresis device for delivering active agents to a biological interface, the iontophoresis device comprising an active electrode assembly and a counter electrode assembly, the active electrode assembly further including:
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an active electrode element operable to provide an electrical potential; and an inner active agent reservoir comprising; a first compartment having a diluent; a second compartment having an active agent; and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding, wherein, when the electrical potential is applied to the active electrode, the polymer complex layer disintegrates to allow the active agent and the diluent to mix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for transdermal administration of an active agent by iontophoresis, comprising:
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positioning an active electrode assembly and a counter electrode assembly of an iontophoresis device on a biological interface of a subject, the active electrode assembly further including an active electrode element operable to provide an electrical potential; and
an inner active agent reservoir comprising a first compartment having a diluent, a second compartment having an active agent, and a polymer complex layer disposed between the first compartment and the second compartment, the polymer complex being formed by a first hydrophilic polymer and a second hydrophilic polymer via hydrogen bonding; andapplying a sufficient amount of electrical current to cause the polymer complex layer to disintegrate such that the diluent and the active agent are mixed, and to administer a therapeutically effective amount of the active agent in the subject for a limited period of time. - View Dependent Claims (21, 22, 23, 24)
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Specification