Microfluidic separator

• US 7,575,681 B2
• Filed: 09/08/2004
• Issued: 08/18/2009
• Est. Priority Date: 07/06/2004
• Status: Active Grant

• Current Assignee: Schlumberger Technology Corporation (Schlumberger NV)
• Original Assignee: Schlumberger Technology Corporation (Schlumberger NV)
• Inventors: Angelescu, Dan Eugen, Clark, Brian Oliver, Wong, Joyce, Raghuraman, Bhavani, Salamitou, Philippe
• Primary Examiner(s): Fortuna; Ana M
• Application Number:
  US10/935,858
• Publication Number:
  US 20060008913A1
• Time in Patent Office: 1,805 Days
• Field of Search: 210/321.6, 210/321.75, 210/257.2, 422100-102, 422/64, 422/68, 422/72, 435/63, 435/45, 166/308.3, 166/380, 166/302
• US Class Current: 210/321.74
• CPC Class Codes: B01D 17/085 with membranes
• CPC Class Codes: B01D 19/0031 by filtration
• CPC Class Codes: B01D 61/18 Apparatus therefor
• CPC Class Codes: B01D 67/0062 by micromachining techniques, e.g. using masking and etching steps, photolithography
• CPC Class Codes: B01L 2200/0673 Handling of plugs of fluid surrounded by immiscible fluid
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2300/0864 comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
• CPC Class Codes: B01L 2300/161 Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502753 characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation separation in general B01D; microapparatus for analysis using electrophoresis G01N27/44791; sample preparation G01N1/28
• CPC Class Codes: E21B 43/38 in the well
• CPC Class Codes: E21B 49/081 with down-hole means for trapping a fluid sample E21B49/10 takes precedence
• CPC Class Codes: E21B 49/10 using side-wall fluid samplers or testers
• CPC Class Codes: G01N 1/4005 by transferring a selected component through a membrane
• CPC Class Codes: G01N 2001/4016 being a selective membrane, e.g. dialysis or osmosis
• CPC Class Codes: G01N 33/28 Oils , i.e. hydrocarbon liquidsgaseous fuels G01N33/225; edible oils or edible fats G01N33/03
• CPC Class Codes: Y10T 436/25375 Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

The present invention provides methods and apparatus for separating and/or analyzing fluids of interest. According to principles of the present invention, fluid analysis is accomplished with microfluidic devices and may be reported in real-time or near real-time in a subterranean environment. In addition or alternative to oilfield applications, the principles of the present invention contemplate separation in a laboratory or other environment for biological sample separation and analytical chemistry applications. The present invention is capable of separating liquid-liquid mixtures or emulsions in a microfluidic device without fouling.

Claims

1. An apparatus, comprising:

a microfluidic device comprising a porous membrane for separating a multiphase mixture in a fluid flow stream within a structure wherein a pressure difference across the porous membrane is maintained below a capillary break-through pressure of a nonwetting fluid phase present in the multiphase mixture;

wherein the porous membrane is arranged substantially tangent to an intended fluid flow direction of the multiphase mixture present in the fluid flow stream and disposed across a fluid sample inlet to the microfluidic device; and

a microsieve structured and arranged adjacent to and downstream of the membrane and includes a capillary fluid separator having microfabricated channels arranged substantially tangent to the fluid stream downstream of the porous membrane.

2. An apparatus according to claim 1, wherein the structure is a submersible housing surrounding the microfluidic device.

3. An apparatus according to claim 1, wherein the membrane comprises one of:

a water-repellant, oil-permeable membrane;

an oil-repellent, water-permeable membrane; and

an oil-and-water-repellent, gas-permeable membrane.

4. An apparatus according to claim 1, wherein the membrane comprises one of:

PTFE, nylon, polyethylene, and polypropylene.

5. An apparatus according to claim 1, wherein the porous membrane is mechanically connected, adhesively connected, or chemically connected to the microsieve.

6. An apparatus according to claim 1, further comprising a downhole oilfield tool having a fluid flow stream, wherein the microfluidic device is disposed in the fluid flow stream and the porous membrane is arranged substantially tangent to a flow direction of the fluid flow stream.

7. An apparatus according to claim 1, wherein the microfluidic device comprises a sample manipulation/analysis module or chip.

8. An apparatus according to claim 1, wherein the microfabricated channels comprise pores of approximately 10 microns or less.

9. An apparatus according to claim 8, further comprising a secondary fluid outlet channel tangentially downstream of the capillary fluid separator.

10. An apparatus according to claim 1, wherein the multiphase fluid flow stream flows at a first flow rate and a separated fluid flow substream of at least one of the phases in the multiphase mixture flows through the microfluidic device at a second flowrate.

11. An apparatus according to claim 10, wherein the pressure difference across the membrane is maintained at a first pressure which ensures that the second flow rate of the separated fluid flow substream is one or more orders of magnitude lower than the first flow rate of the multiphase fluid flow stream, thus preventing the membrane from fouling without the need to backflush.

12. An apparatus according to claim 1, wherein the microsieve is in direct contact with the membrane thus providing a support structure for the membrane while simultaneously minimizing dead volume.

13. An apparatus according to claim 1, wherein the microsieve is made of a network of microchannels or a combination of a network or microchannels and a wire mesh or a network of microchannels and a perforated plate.

14. An apparatus according to claim 1, wherein the microsieve provides a support to the membrane and creates a uniform distribution of pressure over an entire area of the membrane.

15. A microfluidic system for performing fluid analysis, comprising:

a submersible housing having a fluid analyzer and a power supply to provide power to said system;

a substrate for receiving a multiphase mixture through a fluid sample inlet, wherein said substrate interconnects with said submersible housing; and

a membrane disposed across the fluid sample inlet for separating a fluid of interest from the multiphase mixture; and

wherein the substrate includes fabricated channels, such that the fabricated channels are arranged substantially tangent to the fluid stream downstream of the porous membrane.

16. An apparatus, comprising:

a housing having a fluid flow stream, such that the housing is positioned in a downhole oilfield tool;

a microfluidic device positioned in the housing comprising a porous membrane for separating a multiphase mixture in the fluid flow stream wherein a pressure difference across the porous membrane is maintained below a capillary break-through pressure of a nonwetting fluid phase present in the multiphase mixture;

wherein the porous membrane is arranged substantially tangent to an intended fluid flow direction of the multiphase mixture present in the fluid flow stream; and

a microsieve structured and arranged adjacent to and downstream of the porous membrane and includes a capillary fluid separator having microfabricated channels arranged substantially tangent to the fluid stream downstream of the porous membrane.