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Heat shock protein as a targeting agent for endothelium-specific in vivo transduction

  • US 7,575,738 B2
  • Filed: 08/13/2004
  • Issued: 08/18/2009
  • Est. Priority Date: 08/13/2004
  • Status: Expired due to Fees
First Claim
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1. A compound having the formula S-(L)n-Hwherein S is a signal moiety selected from the group consisting of a luminescent dye, a near infrared dye, a paramagnetic ion, a superparamagnetic particle, 11 C, 18F, 52Fe, 62Cu, 64Cu, 67Cu, 67Ga, 68Ga, 86Y, 89Zr, 94mTc, 94Tc, 99mTc, 111 In, 154-158Gd, and 175Lu,L links S to H, wherein L is a linker selected from the group consisting of a covalent bond, polypeptide, protein, organic radical having a valence of at least 2, and chelating agent,H is HSP-70, or a fragment thereof that binds to LOX- 1, andn is either 0 or 1.

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